F. Richards

Publications207
h-index64
Citations26,275
Highly Influential Citations736
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The interpretation of protein structures: estimation of static accessibility.
A program is described for drawing the van der Waal’s surface of a protein molecule. An extension of the program permits the accessibility of atoms, or groups of atoms, to solvent or solute molecules… Expand
  • 5,115
  • 249
  • PDF
Areas, volumes, packing and protein structure.
  • F. Richards
  • Computer Science, Medicine
  • Annual review of biophysics and bioengineering
  • 1 June 1977
TLDR
The protein folding problem remains today one of the most intriguing and funda­ mental questions in biochemistry. Expand
  • 2,126
  • 76
The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy.
Previous studies by Wishart et al. [Wishart, D. S., Sykes, B. D., & Richards, F. M. (1991) J. Mol. Biol. (in press)] have demonstrated that 1H NMR chemical shifts are strongly dependent on the… Expand
  • 1,743
  • 57
Relationship between nuclear magnetic resonance chemical shift and protein secondary structure.
An analysis of the 1H nuclear magnetic resonance chemical shift assignments and secondary structure designations for over 70 proteins has revealed some very strong and unexpected relationships.… Expand
  • 1,518
  • 50
The interpretation of protein structures: total volume, group volume distributions and packing density.
  • F. Richards
  • Chemistry, Medicine
  • Journal of molecular biology
  • 5 January 1974
Following the general procedure of Bernal & Finney (1967) using Voronoi polyhedra, volumes occupied by all the atoms, or groups of atoms, in lysozyme and ribonuclease S have been estimated from the… Expand
  • 788
  • 28
Crystal structure of hen egg-white lysozyme at a hydrostatic pressure of 1000 atmospheres.
The crystal structure of tetragonal hen egg-white lysozyme at a hydrostatic pressure of 1000 atmospheres has been determined by X-ray diffraction to a nominal resolution of 2 A. The crystals,… Expand
  • 282
  • 25
Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes.
We assume that each class of protein has a core structure that is defined by internal residues, and that the external, solvent-contacting residues contribute to the stability of the structure, are of… Expand
  • 1,335
  • 19
A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-Å resolution
The crystal structure of alamethicin in nonaqueous solvent has been determined, and refined at 1.5-Å resolution. The molecular conformation of the three crystallographically independent molecules is… Expand
  • 604
  • 19
An efficient newton‐like method for molecular mechanics energy minimization of large molecules
Techniques from numerical analysis and crystallographic refinement have been combined to produce a variant of the Truncated Newton nonlinear optimization procedure. The new algorithm shows particular… Expand
  • 657
  • 18
  • PDF
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains
Nature 372, 375-379 (1994) IN Table 1 of this letter, binding positions that absolutely require proline are enclosed in a bold box; for the minus class of binding sequences, the P2 binding positions… Expand
  • 135
  • 13