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Nuclear receptor coregulators: cellular and molecular biology.
This review will summarize selected aspects of the current knowledge of the cellular and molecular biology of nuclear receptor coregulators.
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Results indicate that SRC-1 encodes a coactivator that is required for full transcriptional activity of the steroid receptor superfamily.
Molecular mechanisms of action of steroid/thyroid receptor superfamily members.
The role of Ligand in RECEPTOR TRANSFORMATION and ACTIVATION is studied, as well as the role of serotonin, which plays a role in both transformation and inhibition.
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.
Results provide direct support for progesterone's role as a pleiotropic coordinator of diverse reproductive events that together ensure species survival.
A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex
Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators
Steroid receptor coactivator-1 is a histone acetyltransferase
It is shown that SRC-1 possesses intrinsic histone acetyltransferase activity and that it also interacts with another HAT, p300/CBP-associated factor (PCAF), which could be a mechanism by which the activation functions of steroid receptors and associated coactivators enhance formation of a stable preinitiation complex, thereby increasing transcription of specific genes from transcriptionally repressed chromatin templates.
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.
- E. Vegeto, M. M. Shahbaz, D. X. Wen, M. Goldman, B. O’Malley, D. McDonnell
- BiologyMolecular endocrinology
- 1 October 1993
The dual role of hPR-A as an activator or repressor of transcription defines a potential mechanism by which cells can generate dissimilar responses to a single hormone and provides a molecular explanation for the existence of two distinct forms of the hPR.
Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.
The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone.
Activation of PPARgamma coactivator-1 through transcription factor docking.
PGC-1 promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator-1 (SRC-1) and CREB binding protein (CBP)/p300, resulting in a large increase in transcriptional activity.