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Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the… Expand
Nuclear receptor coregulators: cellular and molecular biology.
Nuclear receptor coregulators are coactivators or corepressors that are required by nuclear receptors for efficient transcripitonal regulation. In this context, we define coactivators, broadly, as… Expand
Molecular mechanisms of action of steroid/thyroid receptor superfamily members.
INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 451 STEROID RECEPTOR SUPERFAMILY . . . . . . . . . . . . . . ... . . ... . . . . . 453 PROTEIN-DNA… Expand
A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex
Nuclear receptors play critical roles in the regulation of eukaryotic gene expression. We report the isolation and functional characterization of a novel transcriptional coactivator, termed steroid… Expand
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.
Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to have a functional role in a number of… Expand
Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators
The nuclear receptor (NR) superfamily of transcription factors regulates gene expression in response to endocrine signaling, and recruitment of coregulators affords these receptors considerable… Expand
Steroid receptor coactivator-1 is a histone acetyltransferase
Steroid receptors and coactivator proteins are thought to stimulate gene expression by facilitating the assembly of basal transcription factors into a stable preinitiation complex. What is not clear,… Expand
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.
- E. Vegeto, M. M. Shahbaz, D. X. Wen, M. Goldman, B. O’Malley, D. McDonnell
- Biology, Medicine
- Molecular endocrinology
- 1 October 1993
Two distinct isoforms of the human progesterone receptor (hPR-A and hPR-B) have been identified previously. They differ only in that hPR-B contains an additional 164 amino acids at the amino… Expand
Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.
The in vivo biological function of a steroid receptor coactivator was assessed in mice in which the SRC-1 gene was inactivated by gene targeting. Although in both sexes the homozygous mutants were… Expand
Activation of PPARgamma coactivator-1 through transcription factor docking.
Transcriptional coactivators have been viewed as constitutively active components, using transcription factors mainly to localize their functions. Here, it is shown that PPARgamma coactivator-1… Expand