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The Structure of Haplotype Blocks in the Human Genome
It is shown that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed.
Detecting recent positive selection in the human genome from haplotype structure
A framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations is introduced, and the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection.
Linkage disequilibrium in the human genome
The results illuminate human history, suggesting that LD in northern Europeans is shaped by a marked demographic event about 27,000–53,000 years ago, implying that LD mapping is likely to be practical in this population.
Informativeness of genetic markers for inference of ancestry.
In a worldwide human microsatellite data set, a general measure, the informativeness for assignment (I(n), is introduced, applicable to any number of potential source populations, for determining the amount of information that multiallelic markers provide about individual ancestry.
Complete mitochondrial genome sequences of two extinct moas clarify ratite evolution
This first molecular view of the break-up of Gondwana provides a new temporal framework for speciation events within other Gondwanan biota and can be used to evaluate competing biogeographical hypotheses.
Variation in Genetic Diversity across the Range of North American Brown Bears
Understanding the factors that influence the rate at which natural populations lose genetic diversity is a central aspect of conservation genetics because of the importance of genetic diversity in
mtDna and the islands of the North Atlantic: estimating the proportions of Norse and Gaelic ancestry.
Admixture analyses indicate that the ancestral contributions of mtDNA lineages from Scandinavia to the populations of Iceland, Orkney, the Western Isles, and the Isle of Skye are 37.5%, 35.
Linkage and association analysis of angiotensin I-converting enzyme (ACE)-gene polymorphisms with ACE concentration and blood pressure.
It is found that the two polymorphisms explaining the greatest variation in ACE concentration are significantly associated with BP, through interaction, in this African population sample, demonstrating that allelic interaction may play an important role in the dissection of complex traits such as BP.
mtDNA and the origin of the Icelanders: deciphering signals of recent population history.
The findings indicate that European populations contain a large number of closely related mitochondrial lineages, many of which have not yet been sampled in the current comparative data set, and substantial increases in sample sizes will be needed to obtain valid estimates of the diverse ancestral mixtures that ultimately gave rise to contemporary populations.
Phylogeography and pleistocene evolution in the North American black bear.
Congruence between the pattern of diversity observed in black bears and patterns of forest refuge formation during the Pleistocene supports earlier speculation that Pleistsocene forest fragmentations underlie a common pattern in the phylogeography of North American forest taxa.