The blood-brain barrier: Bottleneck in brain drug development
- W. Pardridge
- BiologyNeuroRx
- 2011
This work has shown that the blood-brain barrier provides the platform for CNS drug delivery programs, which should be developed in parallel with traditional CNS drug discovery efforts in the molecular neurosciences.
Blood-brain barrier delivery.
- W. Pardridge
- BiologyDrug Discovery Today
- 2007
Brain metabolism: a perspective from the blood-brain barrier.
- W. Pardridge
- BiologyPhysiological Reviews
- 1 October 1983
Blood-brain barrier drug targeting: the future of brain drug development.
- W. Pardridge
- Biology, MedicineMolecular Interventions
- 1 March 2003
The functions of the various known transport systems in the brain are reviewed and how the development of BBB drug-targeting programs in pharmaceutical and academic settings may lead to more efficacious treatments are discussed.
Drug Transport across the Blood–Brain Barrier
- W. Pardridge
- Biology, ChemistryJournal of Cerebral Blood Flow and Metabolism
- 1 November 2012
Peptide and antisense radiopharmaceuticals are made brain-penetrating with the combined use of RMT-based delivery systems and avidin–biotin technology to enable new solutions to the problem of BBB drug transport.
Blood-brain barrier biology and methodology.
- W. Pardridge
- BiologyJournal of Neurovirology
- 1999
The classical physiologic techniques may now be correlated with modern biochemical and molecular biological approaches using freshly isolated animal or human brain capillaries to form an 'in vitro BBB' model.
Brain drug delivery of small molecules using immunoliposomes.
- J. Huwyler, D. Wu, W. Pardridge
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 26 November 1996
Specific OX26-mediated targeting of daunomycin to the rat brain was achieved by the use of an immunoliposome-based drug delivery system and determination of brain levels of immunolIPosomes over 24 h revealed that immunolipsomes accumulate in brain tissue.
Drug and gene targeting to the brain with molecular trojan horses
- W. Pardridge
- Biology, ChemistryNature reviews. Drug discovery
- 1 February 2002
Molecular Trojan Horses, such as endogenous peptides, modified proteins or peptidomimetic monoclonal antibodies, are one way of tricking the brain into allowing these molecules to pass.
Drug Targeting to the Brain
- W. Pardridge
- BiologyPharmaceutical Research
- 7 June 2007
The goal of brain drug targeting technology is the delivery of therapeutics across the blood–brain barrier (BBB), including the human BBB. This is accomplished by re-engineering pharmaceuticals to…
CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport
- W. Pardridge
- Biology, ChemistryJournal of Neurochemistry
- 1 May 1998
It is important to merge CNS drug discovery and CNS drug delivery as early as possible in the overall CNS drug development process to avoid termination caused by negligible blood‐brain barrier transport.
...
...