• Publications
  • Influence
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
TLDR
A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death. Expand
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
TLDR
Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis. Expand
Identification and isolation of a membrane protein necessary for leukotriene production
TLDR
A new class of indole leukotriene inhibitor has been described that inhibits the formation of cellular leukOTrienes but has no direct inhibitory effect on soluble 5-LO activity, and these potent agents are used to identify and isolate a novel membrane protein of relative molecular mass 18,000 which is necessary for cellularLeukotrienes synthesis. Expand
Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein
TLDR
The structures show that inhibitors bind in membrane-embedded pockets of FLAP, which suggests how these inhibitors prevent arachidonic acid from binding to FLAP and subsequently being transferred to 5-lipoxygenase, thereby preventing leukotriene biosynthesis. Expand
The membrane organization of leukotriene synthesis.
TLDR
The results indicate that the formation of LTC( 4) and LTB(4) may be determined by the compartmentalization of biosynthetic enzymes in discrete molecular complexes. Expand
The nuclear membrane organization of leukotriene synthesis
TLDR
The supramolecular architecture of LT synthesis is defined by identifying the activation-dependent assembly of novel multiprotein complexes on the outer and inner nuclear membranes of mast cells. Expand
IL-13 as a therapeutic target for respiratory disease.
TLDR
The essential role of IL-13 in asthma is summarized, the relative contributions ofIL-13 and IL-4 to key aspects of the asthmatic phenotype are compared, and novel therapeutic strategies to target this critical cytokine are outlined. Expand
Actin cleavage by CPP-32/apopain during the development of apoptosis
TLDR
The present results indicate that actin is the substrate of CPP-32/apopain(-like) protease both in vitro and in vivo and suggest the role of actin in the control of cell growth and apoptosis. Expand
Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood
TLDR
This study has shown that analysis of PBMCs reveals systemic changes accompanying asthma exacerbation and has laid the foundation for future comparative studies usingPBMCs. Expand
Uncoating of enveloped viruses
...
1
2
3
4
...