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CLSPN gene

Known as: CLSPN, Claspin Gene, claspin 
This gene is involved in checkpoint mediated cell cycle arrest.
National Institutes of Health

Related topics

Related topics

4 relations
CLSPN protein, humanCell Cycle CheckpointsCell Cycle ControlNegative Regulation of Cell Cycle

Papers overview

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Highly Cited
2014
Highly Cited
2014
HERC2-USP20 axis regulates DNA damage checkpoint through Claspin
The DNA damage response triggers cell-cycle checkpoints, DNA repair and apoptosis using multiple post-translational modifications… 
2014
2014
Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.
The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates the retinoblastoma protein (pRb) and… 
2011
2011
Timeless Links Replication Termination to Mitotic Kinase Activation
The mechanisms that coordinate the termination of DNA replication with progression through mitosis are not completely understood… 
2010
2010
Identification of proteins that may directly interact with human RPA.
RPA, which consisted of three subunits (RPA1, 2 and 3), plays essential roles in DNA transactions. At the DNA replication forks… 
Review
2009
Review
2009
Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination
During cell proliferation, DNA damage inflicted by intrinsic or extrinsic genotoxic stresses impose a thereat to DNA replication… 
2008
2008
Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1.
2007
2007
Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1*
ATM and Rad3-related (ATR) is a regulatory kinase that, when activated by hydroxyurea, UV, or human immunodeficiency virus-1 Vpr… 
Highly Cited
2006
Highly Cited
2006
Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function*
Claspin is a checkpoint protein involved in ATR (ataxia telangiectasia mutated- and Rad3-related)-dependent Chk1 activation in… 
2006
2006
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.
The DNA damage checkpoint pathways sense and respond to DNA damage to ensure genomic stability. The ATR kinase is a central… 
Highly Cited
2003
Highly Cited
2003
Phosphorylated Claspin Interacts with a Phosphate-binding Site in the Kinase Domain of Chk1 during ATR-mediated Activation*
Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing incompletely replicated or UV… 
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