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Stat3 as an Oncogene
Abstract STATs are latent transcription factors that mediate cytokine- and growth factor–directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, andExpand
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Stat3 as an Oncogene
STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cellExpand
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Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and endothelia. Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressorExpand
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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
ABSTRACT Accumulating evidence implicates the transcription factor NF-κB as a positive mediator of cell growth, but the molecular mechanism(s) involved in this process remains largely unknown. HereExpand
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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Here, we propose a new model for understanding the Warburg effect in tumor metabolism. Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) in neighboringExpand
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Transforming p21ras Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions (*)
Several different oncogenes and growth factors promote G1 phase progression. Cyclin D1, the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of shortening, the G1Expand
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The mammary gland iodide transporter is expressed during lactation and in breast cancer
The sodium/iodide symporter mediates active iodide transport in both healthy and cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades with considerable successExpand
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Minireview: Cyclin D1: normal and abnormal functions.
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.Expand
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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.
Rac1 and RhoA are members of the Rho family of Ras-related proteins and function as regulators of actin cytoskeletal organization, gene expression, and cell cycle progression. Constitutive activationExpand
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Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.
Caveolin-1 was first identified as a phosphoprotein in Rous sarcoma virus (RSV)-transformed chicken embryo fibroblasts. Tyrosine 14 is now thought to be the principal site for recognition by c-SrcExpand
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