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Stat3 as an Oncogene
TLDR
Substitution of two cysteine residues within the C-terminal loop of the SH2 domain of Stat3 produces a molecule that dimerizes spontaneously, binds to DNA, and activates transcription.
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.
TLDR
Increased beta-catenin levels may promote neoplastic conversion by triggering cyclin D1 gene expression and, consequently, uncontrolled progression into the cell cycle through a LEF-1 binding site in the cyclinD1 promoter.
Stat3 as an Oncogene
TLDR
Substitution of two cysteine residues within the C-terminal loop of the SH2 domain of Stat3 produces a molecule that dimerizes spontaneously, binds to DNA, and activates transcription.
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
TLDR
The results indicate that eNOS activity is up-regulated in Cav-1 null animals, and this activity can be blunted by using a specific NOS inhibitor, nitro-l-arginine methyl ester.
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
TLDR
It is shown that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1, and is identified as an important transcriptional target of NF-α, revealing a mechanism to explain how NF-β is involved in the early phases of the cell cycle to regulate cell growth and differentiation.
Transforming p21ras Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions (*)
TLDR
It is demonstrated that transforming mutants of p21ras induce the cyclin D1 promoter in human trophoblasts, mink lung epithelial cells, and in Chinese hamster ovary fibroblast cell lines, providing evidence for cross-talk between the p 21ras and cell cycle regulatory pathways.
The mammary gland iodide transporter is expressed during lactation and in breast cancer
TLDR
The results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer.
The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
TLDR
In this alternative model of tumorigenesis, the epithelial cancer cells instruct the normal stroma to transform into a wound-healing stroma, providing the necessary energy-rich micro-environment for facilitating tumor growth and angiogenesis, explaining its powerful predictive value.
Minireview: Cyclin D1: normal and abnormal functions.
TLDR
Accumulating evidence suggests that in addition to its original description as a CDK-dependent regulator of the cell cycle, cyclin D1 also conveys cell cycle orCDK-independent functions.
The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation
TLDR
It is shown here that RASSF1A can induce cell cycle arrest by engaging the Rb family cell cycle checkpoint, and it is strongly suggested that Rassf1A is an important human tumor suppressor protein acting at the level of G1/S-phase cell cycle progression.
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