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TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.
Telomere-repeat-encoding RNA (referred to as TERRA) has been identified as a potential component of yeast and mammalian telomeres. We show here that TERRA RNA interacts with severalExpand
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Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.
Transcription factor IID (TFIID) binds to TATA boxes, nucleating the assembly of initiation complexes containing several general transcription factors and RNA polymerase II. Recently, TFIID was shownExpand
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ORC, MCM, and Histone Hyperacetylation at the Kaposi's Sarcoma-Associated Herpesvirus Latent Replication Origin
ABSTRACT The viral genome of Kaposi's sarcoma-associated herpesvirus (KSHV) persists as an extrachromosomal plasmid in latently infected cells. The KSHV latency-associated nuclear antigen (LANA)Expand
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Inhibition of TATA-Binding Protein Function by SAGA Subunits Spt3 and Spt8 at Gcn4-Activated Promoters
ABSTRACT SAGA is a 1.8-MDa yeast protein complex that is composed of several distinct classes of transcription-related factors, including the adaptor/acetyltransferase Gcn5, Spt proteins, and aExpand
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Cohesins localize with CTCF at the KSHV latency control region and at cellular c‐myc and H19/Igf2 insulators
Cohesins, which mediate sister chromatin cohesion, and CTCF, which functions at chromatin boundaries, play key roles in the structural and functional organization of chromosomes. We examined theExpand
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Chromatin Remodeling of the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Promoter Correlates with Reactivation from Latency
ABSTRACT The switch from latent to lytic infection of Kaposi's sarcoma-associated herpesvirus is initiated by the immediate early transcriptional activator protein Rta/open reading frame 50 (ORF50).Expand
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A general mechanism for transcriptional synergy by eukaryotic activators
ONE of the important regulatory concepts to emerge from studies of eukaryotic gene expression is that RNA polymerase II promo-ters and their upstream activators are composed of functional mod-ulesExpand
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Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription.
TFIIA is thought to play an important role in transcriptional regulation in higher eukaryotes, but its precise function is unclear. A human cDNA encoding a protein with 45% identity to the smallExpand
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Editing of Epstein-Barr Virus-encoded BART6 MicroRNAs Controls Their Dicer Targeting and Consequently Affects Viral Latency*
Certain primary transcripts of miRNA (pri-microRNAs) undergo RNA editing that converts adenosine to inosine. The Epstein-Barr virus (EBV) genome encodes multiple microRNA genes of its own. Here weExpand
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Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replication.
Episomal maintenance and DNA replication of EBV origin of plasmid replication (OriP) plasmid maintenance is mediated by the viral encoded origin binding protein, EBNA1, and unknown cellular factors.Expand
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