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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
TLDR
Findings suggest a functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles, which, in turn, suggests a role for BRC a1 in the control of recombination and of genome integrity. Expand
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
TLDR
This study implicates RNF8 as a novel DNA-damage-responsive protein that integrates protein phosphorylation and ubiquitylation signaling and plays a critical role in the cellular response to genotoxic stress. Expand
Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress*
TLDR
It is reported that inhibition of DNA replication by hydroxyurea or ultraviolet irradiation also induces phosphorylation and foci formation of H2AX, and these phospho-H2AX foci colocalize with proliferating cell nuclear antigen, BRCA1, and 53BP1 at the arrested replication fork in S phase cells. Expand
Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair
TLDR
This study reveals an evolutionarily conserved molecular mechanism of targeting DNA repair proteins to DSBs by direct recognition of H4-K20me2 through direct binding of 53BP1 and Crb2 to histone H4. Expand
Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage
TLDR
The data imply that the BRCA1 S phase foci are dynamic physiological elements, responsive to DNA damage, and that B RCA1-containing multiprotein complexes participate in a replication checkpoint response. Expand
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
TLDR
PALB2 is uncovered as the molecular adaptor between the BRCA proteins, and it is suggested that impaired HR repair is one of the fundamental causes for genomic instability and tumorigenesis observed in patients carrying BRC a1, BRCa2, or PALB2 mutations. Expand
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
TLDR
It is suggested that MDC1, as a signal amplifier of the ATM pathway, is vital in controlling proper DNA damage response and maintaining genomic stability. Expand
The BRCT Domain Is a Phospho-Protein Binding Domain
TLDR
It is shown that the BRCA1 BRCT domain directly interacts with phosphorylated BRCa1-Associated Carboxyl-terminal Helicase (BACH1) and this interaction is cell cycle regulated and is required for DNA damage–induced checkpoint control during the transition from G2 to M phase of the cell cycle. Expand
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
TLDR
It is reported here that separate domains of p21 are responsible for interacting with and inhibiting the essential DNA replication factor, proliferating-cell nuclear antigen (PCNA), and the Cdk2-binding domain is sufficient for inhibition of DNA replication based on Xenopus egg extract and for growth suppression in transformed human cells. Expand
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
TLDR
The results suggest that crosstalk between oxygen- and redox-responsive signal transducers occurs through the SIRT1-HIF-1alpha interaction. Expand
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