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CLSPN protein, human

Known as: claspin homolog (Xenopus laevis), human, Claspin, claspin, human 
Claspin (1339 aa, ~151 kDa) is encoded by the human CLSPN gene. This protein is involved in cell cycle arrest in response to errors in DNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Mammalian Timeless is a multifunctional protein that performs essential roles in the circadian clock, chromosome cohesion, DNA… Expand
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2009
2009
ATR (ATM and Rad3-related) initiates a DNA damage signaling pathway in human cells upon DNA damage induced by UV and UV-mimetic… Expand
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Highly Cited
2009
Highly Cited
2009
Claspin is an adaptor protein that facilitates the ataxia telangiectasia and Rad3-related (ATR)-mediated phosphorylation and… Expand
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Highly Cited
2008
Highly Cited
2008
In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show… Expand
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Highly Cited
2007
Highly Cited
2007
We previously showed that checkpoint kinase 1 (Chk1) and Claspin, two DNA-damage checkpoint proteins, were down-regulated by 1,25… Expand
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2006
2006
TopBP1-like proteins, which include Xenopus laevis Xmus101, are required for DNA replication and have been linked to replication… Expand
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Highly Cited
2006
Highly Cited
2006
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… Expand
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Highly Cited
2004
Highly Cited
2004
The ATR and Chk1 kinases are essential to maintain genomic integrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex, activates… Expand
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2004
2004
Claspin is an essential protein for the ATR-dependent activation of the DNA replication checkpoint response in Xenopus and human… Expand
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Highly Cited
2003
Highly Cited
2003
Claspin is a newly identified protein that regulates Chk1 activation in Xenopus. In the present study we investigated the role of… Expand
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