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In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show… Expand We show that Claspin, an adaptor protein required for Chk1 activation, becomes degraded at the onset of mitosis. Claspin… Expand The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… Expand During replicative stress, Claspin mediates the phosphorylation and consequent activation of Chk1 by ATR. We found that during… Expand DNA-damage checkpoints maintain genomic integrity by mediating a cell-cycle delay in response to genotoxic stress or stalled… Expand The checkpoint mediator protein Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing… Expand Claspin is an essential protein for the ATR-dependent activation of the DNA replication checkpoint response in Xenopus and human… Expand Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus… Expand The ATR and Chk1 kinases are essential to maintain genomicintegrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex,activates… Expand Claspin is a newly identified protein that regulates Chk1 activation in Xenopus. In the present study we investigated the role of… Expand