CLSPN protein, human

Known as: claspin homolog (Xenopus laevis), human, Claspin, claspin, human 
Claspin (1339 aa, ~151 kDa) is encoded by the human CLSPN gene. This protein is involved in cell cycle arrest in response to errors in DNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
051020002017

Papers overview

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Highly Cited
2008
Highly Cited
2008
In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show… (More)
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Highly Cited
2007
Highly Cited
2007
UV-induced DNA damage stalls DNA replication forks and activates the intra-S checkpoint to inhibit replicon initiation. In… (More)
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Highly Cited
2006
Highly Cited
2006
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… (More)
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Highly Cited
2006
Highly Cited
2006
We show that Claspin, an adaptor protein required for Chk1 activation, becomes degraded at the onset of mitosis. Claspin… (More)
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Highly Cited
2006
Highly Cited
2006
During replicative stress, Claspin mediates the phosphorylation and consequent activation of Chk1 by ATR. We found that during… (More)
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Highly Cited
2006
Highly Cited
2006
DNA-damage checkpoints maintain genomic integrity by mediating a cell-cycle delay in response to genotoxic stress or stalled… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Checkpoint signaling pathways are of crucial importance for the maintenance of genomic integrity. Within these… (More)
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Highly Cited
2004
Highly Cited
2004
The checkpoint mediator protein Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing… (More)
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Highly Cited
2003
Highly Cited
2003
Claspin is a newly identified protein that regulates Chk1 activation in Xenopus. In the present study we investigated the role of… (More)
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Highly Cited
2000
Highly Cited
2000
We have identified Claspin, a novel protein that binds to Xenopus Chk1 (Xchk1). Binding of Claspin to Xchk1 is highly elevated in… (More)
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