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CLSPN protein, human

Known as: claspin homolog (Xenopus laevis), human, Claspin, claspin, human 
Claspin (1339 aa, ~151 kDa) is encoded by the human CLSPN gene. This protein is involved in cell cycle arrest in response to errors in DNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here, we show… Expand
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Highly Cited
2006
Highly Cited
2006
We show that Claspin, an adaptor protein required for Chk1 activation, becomes degraded at the onset of mitosis. Claspin… Expand
Highly Cited
2006
Highly Cited
2006
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo… Expand
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Highly Cited
2006
Highly Cited
2006
During replicative stress, Claspin mediates the phosphorylation and consequent activation of Chk1 by ATR. We found that during… Expand
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Highly Cited
2006
Highly Cited
2006
DNA-damage checkpoints maintain genomic integrity by mediating a cell-cycle delay in response to genotoxic stress or stalled… Expand
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Highly Cited
2004
Highly Cited
2004
The checkpoint mediator protein Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing… Expand
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Highly Cited
2004
Highly Cited
2004
Claspin is an essential protein for the ATR-dependent activation of the DNA replication checkpoint response in Xenopus and human… Expand
Highly Cited
2004
Highly Cited
2004
Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus… Expand
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Highly Cited
2004
Highly Cited
2004
The ATR and Chk1 kinases are essential to maintain genomicintegrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex,activates… Expand
Highly Cited
2003
Highly Cited
2003
Claspin is a newly identified protein that regulates Chk1 activation in Xenopus. In the present study we investigated the role of… Expand