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Adaptor Proteins, Signal Transducing

Known as: Adapter Signaling Protein, Signal Transducing Adaptor Protein, Adaptor Protein 
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having… 
National Institutes of Health

Related topics

Related topics

49 relations
ABI1 protein, humanFRS3 protein, humanProcess of secretionSH2 domain-containing leukocyte protein, 76-kDa

Narrower (37)

ATG13 protein, humanATRIP protein, humanAbtb2 protein, ratAgtrap protein, mouse

Papers overview

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Highly Cited
2007
Highly Cited
2007
Regulation of NF-κB Activation in T Cells via Association of the Adapter Proteins ADAP and CARMA1
The adapter protein ADAP regulates T lymphocyte adhesion and activation. We present evidence for a previously unrecognized… 
Highly Cited
2002
Highly Cited
2002
Lipid Raft Heterogeneity in Human Peripheral Blood T Lymphoblasts: A Mechanism for Regulating the Initiation of TCR Signal Transduction1
Lateral mobility and spatial organization of proteins within the plasma membrane are likely to mediate the initial events… 
Highly Cited
2000
Highly Cited
2000
Cutting Edge: A Novel Function for the SLAP-130/FYB Adapter Protein in β1 Integrin Signaling and T Lymphocyte Migration1
The role of integrin-mediated signaling events in T cell function remains incompletely characterized. We report here that α4β1… 
Highly Cited
1999
Highly Cited
1999
mGrb10 Interacts with Nedd4*
We have utilized the yeast two-hybrid system to identify proteins interacting with mouse Grb10, an adapter protein known to… 
Highly Cited
1998
Highly Cited
1998
Neuroendocrine Synaptic Vesicles Are Formed In Vitro by Both Clathrin-dependent and Clathrin-independent Pathways
In the neuroendocrine cell line, PC12, synaptic vesicles can be generated from endosomes by a sorting and vesiculation process… 
Highly Cited
1997
Highly Cited
1997
RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes
The related adhesion focal tyrosine kinase (RAFTK), a recently discovered member of the focal adhesion kinase family, has… 
Highly Cited
1996
Highly Cited
1996
Syk-dependent Phosphorylation of Shc
Antigen receptors on T- and B-cells activate Ras through a signaling pathway that results in the tyrosine phosphorylation of Shc… 
Highly Cited
1996
Highly Cited
1996
Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages (*)
Engagement of many cell surface receptors results in tyrosine phosphorylation of an overlapping set of protein substrates. Some… 
Highly Cited
1994
Highly Cited
1994
Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3…
Binding of interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor (GM-CSF) to their high affinity cell surface… 
Highly Cited
1989
Highly Cited
1989
Identification of a clathrin binding subunit in the HA2 adaptor protein complex.
The HA2 adaptor complex, comprising alpha-, beta-, 50-kDa, and 16-kDa subunits, was partially dissociated into its constituents… 
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