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Adaptor Proteins, Signal Transducing

Known as: Adapter Signaling Protein, Signal Transducing Adaptor Protein, Adaptor Protein 
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having… 
National Institutes of Health

Related topics

Related topics

49 relations
ABI1 protein, humanFRS3 protein, humanProcess of secretionSH2 domain-containing leukocyte protein, 76-kDa

Narrower (37)

ATG13 protein, humanATRIP protein, humanAbtb2 protein, ratAgtrap protein, mouse

Papers overview

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Highly Cited
2004
Highly Cited
2004
A domain of Rad9 specifically required for activation of Chk1 in budding yeast
The Rad9 protein is a key adaptor protein in Saccharomyces cerevisiae DNA damage checkpoint pathways. Its adaptor function is to… 
Highly Cited
2003
Highly Cited
2003
Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of Platelets
ABSTRACT Activation of platelets by exposed collagen after vessel wall injury is a primary event in the pathogenesis of stroke… 
Highly Cited
2002
Highly Cited
2002
Lipid Raft Heterogeneity in Human Peripheral Blood T Lymphoblasts: A Mechanism for Regulating the Initiation of TCR Signal Transduction1
Lateral mobility and spatial organization of proteins within the plasma membrane are likely to mediate the initial events… 
Review
1999
Review
1999
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis.
The level of phosphorylation within cells is tightly regulated by the concerted action of protein kinases and protein… 
Highly Cited
1999
Highly Cited
1999
mGrb10 Interacts with Nedd4*
We have utilized the yeast two-hybrid system to identify proteins interacting with mouse Grb10, an adapter protein known to… 
Highly Cited
1997
Highly Cited
1997
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.
CTLA-4 plays a critical role in regulating the immune response. It is mainly located in cytoplasmic vesicles and is expressed… 
Highly Cited
1996
Highly Cited
1996
Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages (*)
Engagement of many cell surface receptors results in tyrosine phosphorylation of an overlapping set of protein substrates. Some… 
Highly Cited
1995
Highly Cited
1995
Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor (*)
The proto-oncogene product, Cbl, is a 120-kDa protein present in lymphocytes that contains numerous PXXP motifs in its COOH… 
Highly Cited
1994
Highly Cited
1994
Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3…
Binding of interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor (GM-CSF) to their high affinity cell surface… 
Highly Cited
1989
Highly Cited
1989
Identification of a clathrin binding subunit in the HA2 adaptor protein complex.
The HA2 adaptor complex, comprising alpha-, beta-, 50-kDa, and 16-kDa subunits, was partially dissociated into its constituents… 
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