Adaptor Proteins, Signal Transducing

Known as: Adapter Signaling Protein, Signal Transducing Adaptor Protein, Adaptor Protein 
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Viral infection triggers activation of transcription factors such as NF-kappaB and IRF3, which collaborate to induce type I… (More)
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Highly Cited
2006
Highly Cited
2006
A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates… (More)
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Highly Cited
2005
Highly Cited
2005
Antiviral immunity against a pathogen is mounted upon recognition by the host of virally associated structures. One of these… (More)
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Highly Cited
2005
Highly Cited
2005
Viral infection or stimulation of TLR3 triggers signaling cascades, leading to activation of the transcription factors IRF-3 and… (More)
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Highly Cited
2005
Highly Cited
2005
Toll-like receptors (TLRs) bind pathogen-specific ligands early in infection, initiating signaling pathways that lead to… (More)
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Review
2003
Review
2003
Sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present within the cytosolic domains of the… (More)
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Highly Cited
2002
Highly Cited
2002
Mammalian Toll-like receptors (TLRs) function as sensors of infection and induce the activation of innate and adaptive immune… (More)
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Highly Cited
2000
Highly Cited
2000
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or… (More)
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Highly Cited
1999
Highly Cited
1999
Gene mutations in invertebrates have been identified that extend life span and enhance resistance to environmental stresses such… (More)
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Highly Cited
1998
Highly Cited
1998
The Toll-mediated signaling cascade using the NF-kappaB pathway has been shown to be essential for immune responses in adult… (More)
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