Adaptor Proteins, Signal Transducing

Known as: Adapter Signaling Protein, Signal Transducing Adaptor Protein, Adaptor Protein 
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having… (More)
National Institutes of Health

Related topics

Related topics

49 relations
ABI1 protein, humanFRS3 protein, humanIn BloodMADD protein
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Narrower (34)

ATG13 protein, humanATRIP protein, humanAZI2 protein, mouseAbtb2 protein, rat
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Papers overview

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Highly Cited
2008
Highly Cited
2008
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Viral infection triggers activation of transcription factors such as NF-kappaB and IRF3, which collaborate to induce type I… (More)
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Highly Cited
2006
Highly Cited
2006
Cryopyrin activates the inflammasome in response to toxins and ATP
A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates… (More)
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Highly Cited
2005
Highly Cited
2005
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Antiviral immunity against a pathogen is mounted upon recognition by the host of virally associated structures. One of these… (More)
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Highly Cited
2005
Highly Cited
2005
VISA is an adapter protein required for virus-triggered IFN-beta signaling.
Viral infection or stimulation of TLR3 triggers signaling cascades, leading to activation of the transcription factors IRF-3 and… (More)
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Highly Cited
2005
Highly Cited
2005
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF.
Toll-like receptors (TLRs) bind pathogen-specific ligands early in infection, initiating signaling pathways that lead to… (More)
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Review
2003
Review
2003
Signals for sorting of transmembrane proteins to endosomes and lysosomes.
Sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present within the cytosolic domains of the… (More)
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Highly Cited
2002
Highly Cited
2002
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
Mammalian Toll-like receptors (TLRs) function as sensors of infection and induce the activation of innate and adaptive immune… (More)
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Highly Cited
2000
Highly Cited
2000
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or… (More)
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Highly Cited
1999
Highly Cited
1999
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Gene mutations in invertebrates have been identified that extend life span and enhance resistance to environmental stresses such… (More)
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Highly Cited
1998
Highly Cited
1998
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
The Toll-mediated signaling cascade using the NF-kappaB pathway has been shown to be essential for immune responses in adult… (More)
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