SH2 domain-containing leukocyte protein, 76-kDa

Known as: SLP-76 signal Transducing adaptor proteins, SH2 Domain-Containing Leukocyte Protein, 76kD, Lymphocyte Cytosolic Protein 2 
Lymphocyte cytosolic protein 2 (533 aa, ~60 kDa) is encoded by the human LCP2 gene. This protein is involved in signal transduction.
National Institutes of Health

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Topic mentions per year

1991-2017
0246819912017

Papers overview

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2010
2010
Imaging studies have identified clusters of kinases and adaptor proteins that serve as centers of signaling at the contact points… (More)
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2006
Highly Cited
2006
The snake venom rhodocytin has been reported to bind to integrin alpha2beta1 and glycoprotein (GP) Ibalpha on platelets, but it… (More)
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2005
Highly Cited
2005
The Tec family kinase Itk is an important regulator of Ca(2+) mobilization and is required for in vivo responses to Th2-inducing… (More)
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2002
2002
Mice deficient in the adaptor Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) exhibit a bleeding… (More)
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Highly Cited
2001
Highly Cited
2001
SLP-76 is an adapter protein required for T-cell receptor (TCR) signaling. In particular, TCR-induced tyrosine phosphorylation… (More)
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2000
Highly Cited
2000
The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement of T cells. LAT is also… (More)
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1999
Highly Cited
1999
In the present study, we have addressed the role of the linker for activation of T cells (LAT) in the regulation of phospholipase… (More)
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1999
1999
Collagen-related peptide (CRP), a collagen homologue, induces platelet activation through a tyrosine kinase-dependent pathway… (More)
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1997
Highly Cited
1997
T cell activation stimulates p56(lck), p59(fyn), ZAP-70, Vav-SLP-76 binding, and IL-2 transcription. Major questions concern the… (More)
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1997
Highly Cited
1997
Previous work has demonstrated that SLP-76, a Grb2-associated tyrosine-phosphorylated protein, augments Interleukin-2 promoter… (More)
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