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Cell Cycle Checkpoints

Known as: Checkpoint, Checkpoints, Cell Cycle, Cell Cycle Checkpoint 
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and… 
National Institutes of Health

Related topics

Related topics

50 relations
ATRIP protein, humanBABAM1 geneBABAM1 protein, humanBRCA1 gene

Narrower (3)

G2/M checkpointmeiotic cell cycle checkpointmitotic cell cycle checkpoint

Papers overview

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Highly Cited
2008
Highly Cited
2008
MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression
ABSTRACT microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of… 
Highly Cited
2005
Highly Cited
2005
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
The essential checkpoint kinase Chk1 is required for cell-cycle delays after DNA damage or blocked DNA replication. However, it… 
Highly Cited
2005
Highly Cited
2005
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
The ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) kinases respond to DNA damage by… 
Highly Cited
2004
Highly Cited
2004
ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia… 
Review
2003
Review
2003
Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression
As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing cancer therapeutic target. Recent… 
Highly Cited
2003
Highly Cited
2003
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel… 
Highly Cited
2001
Highly Cited
2001
Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation
ABSTRACT Cell cycle arrests in the G1, S, and G2phases occur in mammalian cells after ionizing irradiation and appear to protect… 
Highly Cited
2000
Highly Cited
2000
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Chk2 is a protein kinase that is activated in response to DNA damage and may regulate cell cycle arrest. We generated Chk2… 
Highly Cited
1998
Highly Cited
1998
The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response
Highly Cited
1994
Highly Cited
1994
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
In eukaryotes a cell-cycle control termed a checkpoint causes arrest in the S or G2 phases when chromosomes are incompletely… 
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