FAQ

Cell Cycle Checkpoints

Known as: Checkpoint, Checkpoints, Cell Cycle, Cell Cycle Checkpoint 
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and… (More)

Topic mentions per year

Topic mentions per year

1979-2017
020040019792017

Related topics

Related topics

49 relations
ATRIP geneATRIP protein, humanBABAM1 wt AlleleBRCA1 gene
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Narrower (3)

G1/S Transition CheckpointG2/M checkpointmitotic cell cycle checkpoint

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Cell Cycle Checkpoints
physiological aspects
Mitogens
Cell Proliferation
Cell Cycle Arrest
Cell Cycle Control

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Programmed death-1 checkpoint blockade in acute myeloid leukemia.
INTRODUCTION Immune checkpoints are regulatory pathways induced in activated T lymphocytes that regulate antigen responsiveness… (More)
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Highly Cited
2007
Highly Cited
2007
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints… (More)
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Highly Cited
2005
Highly Cited
2005
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
The ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) kinases respond to DNA damage by… (More)
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Highly Cited
2002
Highly Cited
2002
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.
Checkpoint kinase (Chk)1 is an evolutionarily conserved protein kinase that was first identified in fission yeast as an essential… (More)
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Highly Cited
2000
Highly Cited
2000
A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans.
To maintain genomic stability following DNA damage, multicellular organisms activate checkpoints that induce cell cycle arrest or… (More)
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Highly Cited
1999
Highly Cited
1999
GADD45 induction of a G2/M cell cycle checkpoint.
G1/S and G2/M cell cycle checkpoints maintain genomic stability in eukaryotes in response to genotoxic stress. We report here… (More)
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Highly Cited
1999
Highly Cited
1999
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
Germline mutations of the Brca1 tumor suppressor gene predispose women to breast and ovarian cancers. To study mechanisms… (More)
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Highly Cited
1997
Highly Cited
1997
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.
Computer analysis of a conserved domain, BRCT, first described at the carboxyl terminus of the breast cancer protein BRCA1, a p53… (More)
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Highly Cited
1992
Highly Cited
1992
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
Cell cycle checkpoints can enhance cell survival and limit mutagenic events following DNA damage. Primary murine fibroblasts… (More)
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Highly Cited
1992
Highly Cited
1992
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
Cell cycle checkpoints appear to contribute to an increase in cell survival and a decrease in abnormal heritable genetic changes… (More)
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