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Cell Cycle Checkpoints

Known as: Checkpoint, Checkpoints, Cell Cycle, Cell Cycle Checkpoint 
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and… 
National Institutes of Health

Related topics

Related topics

50 relations
ATRIP protein, humanBABAM1 geneBABAM1 protein, humanBRCA1 gene

Narrower (3)

G2/M checkpointmeiotic cell cycle checkpointmitotic cell cycle checkpoint

Papers overview

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Highly Cited
2007
Highly Cited
2007
DNA damage induces Chk1‐dependent centrosome amplification
Centrosomal abnormalities are frequently observed in cancers and in cells with defective DNA repair. Here, we used light and… 
Highly Cited
2005
Highly Cited
2005
Activation of Ataxia Telangiectasia-mutated DNA Damage Checkpoint Signal Transduction Elicited by Herpes Simplex Virus Infection*
Eukaryotic cells are equipped with machinery to monitor and repair damaged DNA. Herpes simplex virus (HSV) DNA replication occurs… 
Highly Cited
2004
Highly Cited
2004
Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing
The replication checkpoint controls the integrity of replicating chromosomes by stabilizing stalled forks, thus preventing the… 
Highly Cited
2003
Highly Cited
2003
Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody*
Chk2 is a protein kinase intermediary in DNA damage checkpoint pathways. DNA damage induces phosphorylation of Chk2 at multiple… 
Highly Cited
2002
Highly Cited
2002
Cnd2 has dual roles in mitotic condensation and interphase
Chromosome condensation requires condensin, which comprises five subunits. Two of these subunits—both being structural… 
Highly Cited
2001
Highly Cited
2001
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.
PURPOSE To define the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of the novel protein kinase inhibitor, UCN-01… 
Highly Cited
2001
Highly Cited
2001
Orc mutants arrest in metaphase with abnormally condensed chromosomes.
The origin recognition complex (ORC) is a six subunit complex required for eukaryotic DNA replication initiation and for… 
Highly Cited
1997
Highly Cited
1997
RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.
We have previously shown that a checkpoint dependent on MEC1 and RAD53 slows the rate of S phase progression in Saccharomyces… 
Highly Cited
1994
Highly Cited
1994
Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells
The protein kinase inhibitor 2-aminopurine induces checkpoint override and mitotic exit in BHK cells which have been arrested in… 
Highly Cited
1993
Highly Cited
1993
RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae.
Exposure of the yeast Saccharomyces cerevisiae to ultraviolet (UV) light, the UV-mimetic chemical 4-nitroquinoline-1-oxide (4NQO… 
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