L. Hartwell

Publications123
h-index69
Citations30,407
Highly Influential Citations1,093
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From molecular to modular cell biology
TLDR
General principles that govern the structure and behaviour of modules may be discovered with help from synthetic sciences such as engineering and computer science, from stronger interactions between experiment and theory in cell biology, and from an appreciation of evolutionary constraints.
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Genetic control of the cell division cycle in yeast.
TLDR
Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle.
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Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
TLDR
It is concluded that the checkpoint in budding yeast consists of overlapping S-phase and G2-phase pathways that respond to incomplete DNA replication and/or DNA damage and cause arret of cells before mitosis.
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Checkpoints: controls that ensure the order of cell cycle events.
TLDR
It appears that some checkpoints are eliminated during the early embryonic development of some organisms; this fact may pose special problems for the fidelity of embryonic cell division.
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Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
TLDR
The results suggest that the CDC13 product functions in telomere metabolism, either in the replication of telomeric DNA or in protecting telomeres from the double-strand break repair system.
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The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.
TLDR
Examinations of the genetic basis for this response in the yeast Saccharomyces cerevisiae indicate that the RAD9 gene product is essential for arrest of cell division induced by DNA damage.
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Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis.
  • L. Hartwell
  • Biology
    Experimental cell research
  • 1 December 1971
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Saccharomyces cerevisiae cell cycle.
TLDR
The bibliography is intended more as a guide to the literature than as a historically accurate record of the development of the field; the authors apologize to the earlier workers whose contributions thus get less explicit credit than they deserve.
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Cell cycle control and cancer.
TLDR
New insights in understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes.
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Coordination of growth with cell division in the yeast Saccharomyces cerevisiae.
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