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From molecular to modular cell biology
General principles that govern the structure and behaviour of modules may be discovered with help from synthetic sciences such as engineering and computer science, from stronger interactions between experiment and theory in cell biology, and from an appreciation of evolutionary constraints.
Genetic control of the cell division cycle in yeast.
Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle.
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
It is concluded that the checkpoint in budding yeast consists of overlapping S-phase and G2-phase pathways that respond to incomplete DNA replication and/or DNA damage and cause arret of cells before mitosis.
Checkpoints: controls that ensure the order of cell cycle events.
It appears that some checkpoints are eliminated during the early embryonic development of some organisms; this fact may pose special problems for the fidelity of embryonic cell division.
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
The results suggest that the CDC13 product functions in telomere metabolism, either in the replication of telomeric DNA or in protecting telomeres from the double-strand break repair system.
The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.
Examinations of the genetic basis for this response in the yeast Saccharomyces cerevisiae indicate that the RAD9 gene product is essential for arrest of cell division induced by DNA damage.
Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis.
- L. Hartwell
- BiologyExperimental cell research
- 1 December 1971
Saccharomyces cerevisiae cell cycle.
- L. Hartwell
- BiologyBacteriological reviews
- 1 June 1974
The bibliography is intended more as a guide to the literature than as a historically accurate record of the development of the field; the authors apologize to the earlier workers whose contributions thus get less explicit credit than they deserve.
Cell cycle control and cancer.
New insights in understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes.