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  • Aravind Subramanian, P. Tamayo, +8 authors J. Mesirov
  • Computer Science, Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 30 September 2005)
  • Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe aExpand
  • Terri A. Addona, Susan E. Abbatiello, +46 authors S. Carr
  • Biology, Medicine
  • Nature Biotechnology
  • 2009 (First Publication: 1 July 2009)
  • Verification of candidate biomarkers relies upon specific, quantitative assays optimized for selective detection of target proteins, and is increasingly viewed as a critical step in the discoveryExpand
  • Brendan MacLean, Daniela M. Tomazela, +5 authors Michael J. MacCoss
  • Medicine, Chemistry
  • Analytical chemistry
  • 2010 (First Publication: 19 November 2010)
  • Proteomics experiments based on Selected Reaction Monitoring (SRM, also referred to as Multiple Reaction Monitoring or MRM) are being used to target large numbers of protein candidates in complexExpand
  • Jeffrey R Whiteaker, Lei Zhao, Leigh R. Anderson, Amanda G. Paulovich
  • Chemistry, Medicine
  • Molecular & Cellular Proteomics
  • 2009 (First Publication: 20 October 2009)
  • There is an urgent need for quantitative assays in verifying and validating the large numbers of protein biomarker candidates produced in modern “-omics” experiments. Stable isotope standards withExpand
  • Amanda G. Paulovich, Christopher D. Armour, Leland H. Hartwell
  • Biology, Medicine
  • Genetics
  • 1998 (First Publication: 1 September 1998)
  • In wild-type Saccharomyces cerevisiae, a checkpoint slows the rate of progression of an ongoing S phase in response to exposure to a DNA-alkylating agent. Mutations that eliminate S phase regulationExpand
  • Steven A. Carr, Susan E. Abbatiello, +42 authors Susan T. Weintraub
  • Medicine, Biology
  • Molecular & Cellular Proteomics
  • 2014 (First Publication: 17 January 2014)
  • Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction monitoring (MRM) to study biological and biomedical questions is well underway in the proteomics community. SuccessfulExpand