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CDC7 protein, human

Known as: HsCDC7, CDC7 Cell Division Cycle 7-Like 1 (S. cerevisiae), huCDC7 
Cell division cycle 7-related protein kinase (574 aa, ~64 kDa) is encoded by the human CDC7 gene. This protein plays a role in protein… 
National Institutes of Health

Related topics

Related topics

26 relations
CDC7 geneCDC7 wt AlleleCDK2 protein, humanCDK3 protein, human

Broader (2)

Cell Cycle ProteinsProtein-Serine-Threonine Kinases

Narrower (1)

Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2

Papers overview

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Highly Cited
2008
Highly Cited
2008
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.
Cdc7 is an essential kinase that promotes DNA replication by activating origins of replication. Here, we characterized the potent… 
Highly Cited
2002
Highly Cited
2002
PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane
Sphingosine-1-phosphate (S1P) is a highly bioactive sphingolipid involved in diverse biological processes leading to changes in… 
Review
2002
Review
2002
Cdc7 kinase complex: A key regulator in the initiation of DNA replication
DNA replication results from the action of a staged set of highly regulated processes. Among the stages of DNA replication… 
Highly Cited
2000
Highly Cited
2000
Pharmacological characterization of small‐conductance Ca2+‐activated K+ channels stably expressed in HEK 293 cells
Three genes encode the small‐conductance Ca2+‐activated K+ channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK… 
Highly Cited
2000
Highly Cited
2000
Evidence for Sequential Action of cdc7 and cdk2 Protein Kinases during Initiation of DNA Replication in Xenopus Egg Extracts*
To investigate how the protein kinase cdc7 stimulates DNA replication in metazoans, a soluble cell-free replication system… 
Highly Cited
1999
Highly Cited
1999
Mammalian Cdc7–Dbf4 protein kinase complex is essential for initiation of DNA replication
The Cdc7–Dbf4 kinase is essential for regulating initiation of DNA replication in Saccharomyces cerevisiae. Previously, we… 
Highly Cited
1998
Highly Cited
1998
The Cdc7 protein kinase is required for origin firing during S phase.
The Cdc7p protein kinase plays an essential, but undefined, role promoting S phase in the budding yeast, Saccharomyces cerevisiae… 
Highly Cited
1998
Highly Cited
1998
Cdc7 is required throughout the yeast S phase to activate replication origins.
The long-standing conclusion that the Cdc7 kinase of Saccharomyces cerevisiae is required only to trigger S phase has been… 
Highly Cited
1995
Highly Cited
1995
hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication.
Degenerate oligonucleotide‐directed polymerase chain reaction was conducted to clone a possible Schizosaccharomyces pombe… 
Highly Cited
1993
Highly Cited
1993
Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein
Yeast Cdc7 protein kinase and Dbf4 protein are both required for the initiation of DNA replication at the G1/S phase boundary of… 
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