Principles of bioactive lipid signalling: lessons from sphingolipids
An understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action is required to understand the mechanisms of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking.
An overview of sphingolipid metabolism: from synthesis to breakdown.
- Christopher R. Gault, L. Obeid, Y. Hannun
- Biology, ChemistryAdvances in Experimental Medicine and Biology
- 2010
This chapter will pay tribute to the complex regulation of simple sphingolipids, a class of lipids defined by their eighteen carbon amino-alcohol backbones that play significant roles in membrane biology and provide many bioactive metabolites that regulate cell function.
Sphingolipids and their metabolism in physiology and disease
These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingoipid metabolism to key human diseases.
Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase*
- C. Luberto, D. Hassler, Gary K. Smith
- Biology, ChemistryJournal of Biological Chemistry
- 25 October 2002
GW4869 was able, in a dose-dependent manner, to significantly protect from cell death as measured by nuclear condensation, caspase activation, PARP degradation, and trypan blue uptake, therefore localizing N-SMase activation upstream of mitochondrial dysfunction.
Programmed cell death induced by ceramide.
- L. Obeid, C. Linardic, L. Karolak, Y. Hannun
- Biology, ChemistryScience
- 19 March 1993
The effects of C2-ceramide on DNA fragmentation were prevented by the protein kinase C activator phorbol 12-myristate 13-acetate, which suggests the existence of two opposing intracellular pathways in the regulation of apoptosis.
Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death*
- Bin Liu, N. Andrieu-Abadie, T. Levade, Ping Zhang, L. Obeid, Y. Hannun
- Biology, ChemistryJournal of Biological Chemistry
- 1 May 1998
Evidence is provided to demonstrate that depletion of GSH is dependent on activity of interleukin-1β-converting enzyme-like proteases but is upstream of the site of action of Bcl-2 and of the execution phase caspases.
Ceramide synthases at the centre of sphingolipid metabolism and biology.
The function of CerSs as critical regulators of sphingolipid metabolism is discussed, their unique characteristics are highlighted and the emerging roles of Cer Ss in regulating programmed cell death, cancer and many other aspects of biology are explored.
Sphingosine kinase: biochemical and cellular regulation and role in disease.
- Tarek A. Taha, Y. Hannun, L. Obeid
- Biology, ChemistryJournal of biochemistry and molecular biology
- 31 March 2006
This review is geared at mechanisms of regulation of sphingosine kinase and the coming to light of its role in disease.
Role for sphingosine kinase 1 in colon carcinogenesis
- T. Kawamori, T. Kaneshiro, L. Obeid
- BiologyThe FASEB Journal
- 1 February 2009
Results are the first in vivo evidence that the SphK1/S1P pathway contributes to colon carcinogenesis and that inhibition of this pathway is a potential target for chemoprevention.
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