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The Protein Kinase Complement of the Human Genome
TLDR
The protein kinase complement of the human genome is catalogued using public and proprietary genomic, complementary DNA, and expressed sequence tag sequences to provide a starting point for comprehensive analysis of protein phosphorylation in normal and disease states and a detailed view of the current state of human genome analysis through a focus on one large gene family.
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
TLDR
Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1
  • S. Hanks, T. Hunter
  • Biology, Chemistry
    FASEB journal : official publication of the…
  • 1 May 1995
TLDR
The eukaryotic protein kinases make up a large superfamily of homologous proteins, and a classification scheme can be founded on a kinase domain phylogeny, which reveals families of enzymes that have related substrate specificities and modes of regulation.
Oncogenic kinase signalling
TLDR
How oncogenic conversion of protein kinases results from perturbation of the normal autoinhibitory constraints on kinase activity is emphasized and an update is provided on the role of deregulated PI(3)K/Akt and mammalian target of rapamycin/p70S6K signalling in human malignancies.
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
TLDR
It is shown that adhesion of murine NIH3T3 fibroblasts to fibronectin promotes SH2-domain-mediated association of the GRB2 adaptor protein and the c-Src protein-tyrosine kinase (PTK) with FAK in vivo, and also results in activation of mitogen-activated protein Kinase (MAPK).
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