• Publications
  • Influence
Principles of bioactive lipid signalling: lessons from sphingolipids
  • Y. Hannun, L. Obeid
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 February 2008
TLDR
An understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action is required to understand the mechanisms of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking. Expand
Biologically active sphingolipids in cancer pathogenesis and treatment
TLDR
This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid. Expand
Functions of Ceramide in Coordinating Cellular Responses to Stress
  • Y. Hannun
  • Biology, Medicine
  • Science
  • 13 December 1996
TLDR
A spectrum of inducers of ceramide accumulation and the nature of Ceramide-mediated responses suggest that ceramide is a key component of intracellular stress response pathways. Expand
An overview of sphingolipid metabolism: from synthesis to breakdown.
TLDR
This chapter will pay tribute to the complex regulation of simple sphingolipids, a class of lipids defined by their eighteen carbon amino-alcohol backbones that play significant roles in membrane biology and provide many bioactive metabolites that regulate cell function. Expand
Sphingolipids and their metabolism in physiology and disease
  • Y. Hannun, L. Obeid
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 March 2018
TLDR
These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingoipid metabolism to key human diseases. Expand
Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase*
TLDR
GW4869 was able, in a dose-dependent manner, to significantly protect from cell death as measured by nuclear condensation, caspase activation, PARP degradation, and trypan blue uptake, therefore localizing N-SMase activation upstream of mitochondrial dysfunction. Expand
Ceramide in apoptosis: an overview and current perspectives.
TLDR
This review summarizes recent findings and discusses insights from studies of ceramide metabolism, topology, and effector actions, promising an accelerated phase in defining the molecular and biochemical details of the role of Ceramide in apoptosis. Expand
The sphingolipid salvage pathway in ceramide metabolism and signaling.
TLDR
This review focuses on the salvage pathway in ceramide metabolism, its regulation, its experimental analysis, and emerging biological functions. Expand
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide
TLDR
It is shown that human FAPP2 is a glucosylceramide-transfer protein that has a pivotal role in the synthesis of complex glycosphingolipids, key structural and signalling components of the plasma membrane. Expand
The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind*
  • Y. Hannun, L. Obeid
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 19 July 2002
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