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Principles of bioactive lipid signalling: lessons from sphingolipids
An understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action is required to understand the mechanisms of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking.
An overview of sphingolipid metabolism: from synthesis to breakdown.
- Christopher R. Gault, L. Obeid, Y. Hannun
- Biology, ChemistryAdvances in experimental medicine and biology
This chapter will pay tribute to the complex regulation of simple sphingolipids, a class of lipids defined by their eighteen carbon amino-alcohol backbones that play significant roles in membrane biology and provide many bioactive metabolites that regulate cell function.
Biologically active sphingolipids in cancer pathogenesis and treatment
This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
Functions of Ceramide in Coordinating Cellular Responses to Stress
- Y. Hannun
- Biology, ChemistryScience
- 13 December 1996
A spectrum of inducers of ceramide accumulation and the nature of Ceramide-mediated responses suggest that ceramide is a key component of intracellular stress response pathways.
Sphingolipids and their metabolism in physiology and disease
These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingoipid metabolism to key human diseases.
Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase*
- C. Luberto, D. Hassler, Gary K. Smith
- Biology, ChemistryThe Journal of Biological Chemistry
- 25 October 2002
GW4869 was able, in a dose-dependent manner, to significantly protect from cell death as measured by nuclear condensation, caspase activation, PARP degradation, and trypan blue uptake, therefore localizing N-SMase activation upstream of mitochondrial dysfunction.
Ceramide activates heterotrimeric protein phosphatase 2A.
Ceramide in apoptosis: an overview and current perspectives.
The sphingolipid salvage pathway in ceramide metabolism and signaling.
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide
It is shown that human FAPP2 is a glucosylceramide-transfer protein that has a pivotal role in the synthesis of complex glycosphingolipids, key structural and signalling components of the plasma membrane.