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CD80 Antigens

Known as: B Cell Activation Antigen, B7 1 Costimulatory Molecule, B7-1 Antigen 
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low… 
National Institutes of Health

Related topics

Related topics

16 relations

Broader (2)

B7 AntigensSurface Antigens
CD28 AntigensCD80 geneCD80 wt AlleleIn Blood

Narrower (2)

CD86 AntigenT-Lymphocyte Activation Antigen CD80, human

Papers overview

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Highly Cited
2010
Highly Cited
2010
Induction of Kidney Allograft Tolerance by Soluble CD83 Associated With Prevalence of Tolerogenic Dendritic Cells and Indoleamine 2,3-Dioxygenase
Background. Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that… 
Highly Cited
2008
Highly Cited
2008
Chlamydia muridarum Infection Subverts Dendritic Cell Function to Promote Th2 Immunity and Airways Hyperreactivity
There is strong epidemiological evidence that Chlamydia infection can lead to exacerbation of asthma. However, the mechanism(s… 
Highly Cited
2002
Highly Cited
2002
Functional IL-10 Deficiency in the Lung of Cystic Fibrosis (cftr−/−) and IL-10 Knockout Mice Causes Increased Expression and Function of B7 Costimulatory Molecules on Alveolar Macrophages1
Alveolar macrophages are poor APCs that only minimally express B7 costimulatory molecules. Because our previous data suggest that… 
Highly Cited
2002
Highly Cited
2002
Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation
Background. Antibodies and fusion proteins specific for CD80, CD86, and CD154 have shown promise as agents capable of inducing… 
Highly Cited
2002
Highly Cited
2002
Effect of administration of CTLA4-Ig as protein or cDNA on corneal allograft survival.
PURPOSE To examine the role of the CD28-CD80-CD86 pathway of T-lymphocyte costimulation in corneal allograft rejection and the… 
Highly Cited
2001
Highly Cited
2001
INDUCTION THERAPY WITH MONOCLONAL ANTIBODIES SPECIFIC FOR CD80 AND CD86 DELAYS THE ONSET OF ACUTE RENAL ALLOGRAFT REJECTION IN NON-HUMAN PRIMATES1
CD80 and CD86 (also known as B7–1 and B7–2, respectively) are both ligands for the T cell costimulatory receptors CD28 and CD152… 
Highly Cited
2000
Highly Cited
2000
Costimulation by B7-1 and B7-2 Is Required for Autoimmune Disease in MRL-Faslpr Mice1
Autoimmune lupus nephritis is dependent on infiltrating autoreactive leukocytes and Igs. B7 costimulatory molecules (B7-1 and B7… 
Highly Cited
1999
Highly Cited
1999
CD80 and CD86 Are Not Equivalent in Their Ability to Induce the Tyrosine Phosphorylation of CD28*
Ligation of either CD80 (B7-1) or CD86 (B7-2), two principal ligands for CD28, is thought to skew the immune response toward Th1… 
Highly Cited
1998
Highly Cited
1998
Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.
CD70 (CD27 ligand (CD27L)), CD153 (CD30L), and CD154 (CD40L) are members of the tumor necrosis factor family of costimulatory… 
Highly Cited
1994
Highly Cited
1994
Effect of CTLA‐4 chimeric protein on rat autoimmune anti‐glomerular basement membrane glomerulonephritis
The interaction of the T cell receptor with the antigen/major histocompatibility class II complex is insufficient to induce… 
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