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T-Lymphocyte Activation Antigen CD80, human

Known as: CD28LG, CD80 Antigen, CD28 Antigen Ligand 1 
T-lymphocyte activation antigen CD80 (288 aa, ~33 kDa) is encoded by the human CD80 gene. This protein is involved in the regulation of T-cell… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However… Expand
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Highly Cited
1997
Highly Cited
1997
Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and… Expand
Highly Cited
1996
Highly Cited
1996
T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates… Expand
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Highly Cited
1996
Highly Cited
1996
  • J. Greene, Gina M. Leytze, +4 authors Peter S. Linsley
  • The Journal of Biological Chemistry
  • 1996
  • Corpus ID: 25957794
T lymphocyte receptors CD28 and CTLA-4 bind costimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and… Expand
Highly Cited
1996
Highly Cited
1996
Colon cancer cells express potentially immunogenic proteins but are not rejected by the immune system. To induce an effective… Expand
Review
1995
Review
1995
Howard Hughes Medical Institute Department of Medicine and Department of Molecular Genetics and Cell Biology Gwen Knapp Center… Expand
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Highly Cited
1995
Highly Cited
1995
Efficient initiation of a CD4 T cell response requires both activation through the TCR and costimulation provided by molecules on… Expand
Highly Cited
1995
Highly Cited
1995
Antigen-specific T cell activation depends initially on the interaction of the T cell receptor (TCR) with peptide/MHC. In… Expand
Highly Cited
1994
Highly Cited
1994
T cell surface receptors CD28 and CTLA-4 are homologous members of the immunoglobulin superfamily (IgSF), each comprising a… Expand
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Highly Cited
1994
Highly Cited
1994
Activation of T cells requires at least two signals: an antigen-specific signal delivered through the T-cell receptor and a… Expand
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