T-Lymphocyte Activation Antigen CD80, human
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The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However… Expand Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and… Expand T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates… Expand T lymphocyte receptors CD28 and CTLA-4 bind costimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and… Expand Colon cancer cells express potentially immunogenic proteins but are not rejected by the immune system. To induce an effective… Expand Howard Hughes Medical Institute Department of Medicine and Department of Molecular Genetics and Cell Biology Gwen Knapp Center… Expand Efficient initiation of a CD4 T cell response requires both activation through the TCR and costimulation provided by molecules on… Expand Antigen-specific T cell activation depends initially on the interaction of the T cell receptor (TCR) with peptide/MHC. In… Expand T cell surface receptors CD28 and CTLA-4 are homologous members of the immunoglobulin superfamily (IgSF), each comprising a… Expand Activation of T cells requires at least two signals: an antigen-specific signal delivered through the T-cell receptor and a… Expand