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T-Lymphocyte Activation Antigen CD80, human

Known as: CD28LG, CD80 Antigen, CD28 Antigen Ligand 1 
T-lymphocyte activation antigen CD80 (288 aa, ~33 kDa) is encoded by the human CD80 gene. This protein is involved in the regulation of T-cell… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However… Expand
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Highly Cited
1999
Highly Cited
1999
The costimulatory molecules B7-1 and B7-2 regulate T lymphocyte activation by delivering activating signals through CD28 and… Expand
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1999
1999
Occupancy of CTLA-4 (cytotoxic T-lymphocyte antigen-4 or CD152) negatively regulates the activation of mouse T lymphocytes, as… Expand
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Highly Cited
1997
Highly Cited
1997
Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and… Expand
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Highly Cited
1996
Highly Cited
1996
T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates… Expand
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Highly Cited
1996
Highly Cited
1996
T lymphocyte receptors CD28 and CTLA-4 bind costimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and… Expand
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Highly Cited
1996
Highly Cited
1996
Colon cancer cells express potentially immunogenic proteins but are not rejected by the immune system. To induce an effective… Expand
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Highly Cited
1996
Highly Cited
1996
A number of cytokines and costimulatory molecules involved in immune activation have recently been identified including IL-12, a… Expand
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Highly Cited
1995
Highly Cited
1995
Efficient initiation of a CD4 T cell response requires both activation through the TCR and costimulation provided by molecules on… Expand
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1995
1995
The co-stimulatory B7 molecules (B7-1 and B7-2) are expressed on professional antigen-presenting cells in mice. In this study, we… Expand
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