T-Lymphocyte Activation Antigen CD80, human

Known as: CD28LG, CD80 Antigen, CD28 Antigen Ligand 1 
T-lymphocyte activation antigen CD80 (288 aa, ~33 kDa) is encoded by the human CD80 gene. This protein is involved in the regulation of T-cell… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
0204019932017

Papers overview

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Highly Cited
2003
Highly Cited
2003
The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. However… (More)
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Highly Cited
1999
Highly Cited
1999
The costimulatory molecules B7-1 and B7-2 regulate T lymphocyte activation by delivering activating signals through CD28 and… (More)
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Highly Cited
1997
Highly Cited
1997
Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and… (More)
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Highly Cited
1996
Highly Cited
1996
Colon cancer cells express potentially immunogenic proteins but are not rejected by the immune system. To induce an effective… (More)
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Highly Cited
1996
Highly Cited
1996
T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates… (More)
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Highly Cited
1996
Highly Cited
1996
T lymphocyte receptors CD28 and CTLA-4 bind costimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and… (More)
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Highly Cited
1995
Highly Cited
1995
Efficient initiation of a CD4 T cell response requires both activation through the TCR and costimulation provided by molecules on… (More)
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Highly Cited
1995
Highly Cited
1995
Antigen-specific T cell activation depends initially on the interaction of the T cell receptor (TCR) with peptide/MHC. In… (More)
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Highly Cited
1994
Highly Cited
1994
Activation of T cells requires at least two signals: an antigen-specific signal delivered through the T-cell receptor and a… (More)
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Highly Cited
1994
Highly Cited
1994
T cell surface receptors CD28 and CTLA-4 are homologous members of the immunoglobulin superfamily (IgSF), each comprising a… (More)
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