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T-Lymphocyte Activation Antigen CD80, human

Known as: CD28LG, CD80 Antigen, CD28 Antigen Ligand 1 
T-lymphocyte activation antigen CD80 (288 aa, ~33 kDa) is encoded by the human CD80 gene. This protein is involved in the regulation of T-cell… 
National Institutes of Health

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22 relations
B-LymphocytesCD80 geneCD80 wt AlleleCell Adhesion

Broader (1)

CD80 Antigens

Papers overview

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2001
2001
Mass, charge, and subcellular localization of a unique secretory product identified by the basophil-specific antibody BB1.
BACKGROUND BB1 is a basophil-specific mAb (Lab Invest 1999;79:27-38). The identity of the corresponding antigen has not been… 
2000
2000
New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus
The crucial role of costimulatory molecules, CD28, CTLA-4, CD80 and CD86, for T cell activation and inhibition has been… 
1999
1999
B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite.
T cells require CD28/CTLA-4 costimulatory molecule interactions in addition to Ag-specific signals through the TCR for in vivo… 
Highly Cited
1998
Highly Cited
1998
Initiation of the autologous mixed lymphocyte reaction requires the expression of costimulatory molecules B7-1 and B7-2 on human peripheral blood dendritic cells.
The human autologous mixed lymphocyte reaction (AMLR) consists of a proliferative response of primarily CD4+ T lymphocytes… 
Highly Cited
1998
Highly Cited
1998
Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis.
B7/CD28-mediated costimulation is a promising target for therapeutic intervention in autoimmune diseases. However, studies… 
Highly Cited
1997
Highly Cited
1997
Expression of costimulatory molecules B7‐1 (CD80) and B7‐2 (CD86) on human hepatocellular carcinoma
Costimulation mediated by costimulatory molecules, such as B7‐1 and B7‐2, which are ligands for the CD28/cytolytic T lymphocyte… 
Highly Cited
1995
Highly Cited
1995
Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation
The co‐stimulatory B7 molecules (B7‐1 and B7‐2) are expressed on professional antigen‐presenting cells in mice. In this study, we… 
Highly Cited
1995
Highly Cited
1995
Rapid induction of a novel costimulatory activity on B cells by CD40 ligand
Highly Cited
1995
Highly Cited
1995
Lipopolysaccharide Effectively Up‐Regulates B7‐1 (CD80) Expression and Costimulatory Function of Human Monocytes
The influence of lipopolysaccharide (LPS) and various cytokines on the expression of the costimulatory molecule B7‐1 and… 
Highly Cited
1995
Highly Cited
1995
In situ expression of B7 and CD28 receptor families in human malignant melanoma: Relevance for T‐cell‐mediated anti‐tumor immunity
Work in animal models has suggested that interactions of members of the B7 receptor family (e.g., B7–1, B7–2) on tumor cells with… 
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