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B7 Antigens

Known as: B7 Molecules, B7 antigen, B 7 Antigen 
A family of cell-surface proteins found on ANTIGEN-PRESENTING CELLS. B7 antigens are ligands for specific cell surface receptor subtypes found on T… 
National Institutes of Health

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Related topics

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Narrower (3)

CD80 AntigensNCR3LG1 protein, humanSkint2 protein, mouse
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2001
Highly Cited
2001
CD28-independent Costimulation of T Cells in Alloimmune Responses1
T cell costimulation by B7 molecules plays an important role in the regulation of alloimmune responses. Although both B7-1 and B7… 
Highly Cited
2000
Highly Cited
2000
Loss of B7.2 (CD86) and intracellular adhesion molecule 1 (CD54) expression is associated with decreased tumor-infiltrating T lymphocytes in diffuse B-cell large-cell lymphoma.
Tumor-infiltrating CD8+ T-lymphocytes (T-TILs) are thought to be relevant to immunosurveillance of several tumor types including… 
Highly Cited
1999
Highly Cited
1999
B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism
For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2… 
Highly Cited
1997
Highly Cited
1997
Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.
The costimulatory signal provided to T cells through CD28/CTLA-4 interactions is required for in vivo Th cell effector function… 
Highly Cited
1997
Highly Cited
1997
CD28 costimulation increases CD8+ cell suppression of HIV replication.
A subset of CD8+ T lymphocytes that expresses CD28, a membrane receptor for B7 differentiation Ags found on APCs, is primarily… 
1997
1997
Induction of donor-specific T cell anergy by portal venous injection of allogeneic cells.
Highly Cited
1995
Highly Cited
1995
A reassessment of the role of B7-1 expression in tumor rejection
Introduction of the B7-1 gene into murine tumor cells can result in rejection of the B7-1 transductants and, in some cases… 
Highly Cited
1995
Highly Cited
1995
Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation
The co‐stimulatory B7 molecules (B7‐1 and B7‐2) are expressed on professional antigen‐presenting cells in mice. In this study, we… 
Highly Cited
1992
Highly Cited
1992
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.
We demonstrate that the murine B7 (mB7) protein is a potent costimulatory molecule for the activation of resting murine CD4+ T… 
Highly Cited
1992
Highly Cited
1992
Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.
We have previously shown that the murine B7 (mB7) molecule, when expressed in Chinese hamster ovary cells in stable fashion, can… 
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