Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

@article{Reiser1992MurineBA,
  title={Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.},
  author={Hans Reiser and Gordon J Freeman and Ziba Razi-Wolf and Claude D. Gimmi and Baruj Benacerraf and Lee M. Nadler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 1},
  pages={
          271-5
        }
}
We demonstrate that the murine B7 (mB7) protein is a potent costimulatory molecule for the activation of resting murine CD4+ T cells through the T-cell receptor (TCR)/CD3 complex. Stable mB7-transfected Chinese hamster ovary cells, but not vector-transfected controls, synergize with anti-CD3 monoclonal antibody and Con A-induced T-cell activation, resulting ultimately in proliferation. mB7 exerted its effect by inducing production of interleukin 2 and expression of the interleukin 2 receptor… CONTINUE READING

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