CD28 costimulation increases CD8+ cell suppression of HIV replication.

@article{Barker1997CD28CI,
  title={CD28 costimulation increases CD8+ cell suppression of HIV replication.},
  author={Edward L. Barker and Katharine N. Bossart and Sue H. Fujimura and JayA. Levy},
  journal={Journal of immunology},
  year={1997},
  volume={159 10},
  pages={
          5123-31
        }
}
A subset of CD8+ T lymphocytes that expresses CD28, a membrane receptor for B7 differentiation Ags found on APCs, is primarily responsible for the noncytotoxic suppression of HIV replication in CD4+ cells of HIV-infected individuals. Optimal inhibition of HIV production by CD8+ cells occurs after triggering the CD28 molecule on the cells with anti-CD28 Abs during stimulation. Blocking the interaction of the CD28 and B7 molecules with a CTLA4Ig fusion protein abrogates the ability of autologous… CONTINUE READING

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