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CD28 Antigens

Known as: TP44 Receptor, Antigens, CD28, CD28 
Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

AB103T-Cell-Specific Surface Glycoprotein CD28, human

Broader (1)

CD Antigens
CD28 geneCD28 wt AlleleCD80 AntigensCTLA4 gene

Papers overview

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Highly Cited
1999
Highly Cited
1999
CD28-deficient mice are highly resistant to collagen-induced arthritis.
CD28 provides a critical costimulatory signal in Ag-specific T cell activation. Recent studies have revealed an important role… 
Highly Cited
1999
Highly Cited
1999
CD80 and CD86 Are Not Equivalent in Their Ability to Induce the Tyrosine Phosphorylation of CD28*
Ligation of either CD80 (B7-1) or CD86 (B7-2), two principal ligands for CD28, is thought to skew the immune response toward Th1… 
Highly Cited
1997
Highly Cited
1997
Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells.
The costimulatory receptor CD28 is important in the development of both Th1 and Th2 responses. To further assess the requirement… 
Highly Cited
1997
Highly Cited
1997
CD28 costimulation increases CD8+ cell suppression of HIV replication.
A subset of CD8+ T lymphocytes that expresses CD28, a membrane receptor for B7 differentiation Ags found on APCs, is primarily… 
Highly Cited
1996
Highly Cited
1996
Protection against lethal toxic shock by targeted disruption of the CD28 gene
Toxic shock syndrome (TSS) is a multi system disorder resulting from superantigen-mediated cytokine production. Nearly 90% of the… 
Highly Cited
1995
Highly Cited
1995
Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.
CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the… 
Review
1995
Review
1995
Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule- 4 receptors during T cell activation?
C Ytotoxic T lymphocyte-assodated molecule-4 (CTLA-4) is a lymphocyte cell surface receptor originally discovered in a search for… 
Highly Cited
1994
Highly Cited
1994
CTLA4Ig treatment ameliorates the lethality of murine graft-versus-host disease across major histocompatibility complex barriers.
Graft-versus-host disease (GVHD), a pathological condition associated with BMT, results from activation of donor T lymphocytes by… 
Highly Cited
1992
Highly Cited
1992
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells
CD28 is an adhesion receptor expressed as a 44-kD dimer on the surface of a major subset of human T cells. The CD28 receptor… 
Highly Cited
1989
Highly Cited
1989
Activation of human T cell clones and Jurkat cells by cross-linking class I MHC molecules.
Cross-linking class I MHC molecules on human T cell clones by reacting them with various mAb directed at either monomorphic or… 
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