CASP2 protein, human

Known as: CASP-2, caspase 2, apoptosis-related cysteine protease protein, human, ICH1 
Caspase-2 (452 aa, ~51 kDa) is encoded by the human CASP2 gene. This protein is involved in cell cycle arrest, apoptosis and proteolysis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
024619942018

Papers overview

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2015
2015
OBJECTIVE Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific… (More)
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2014
2014
CASP2/caspase 2 plays a role in aging, neurodegeneration, and cancer. The contributions of CASP2 have been attributed to its… (More)
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2006
2006
PS-341 (bortezomib) is a potent and reversible proteosome inhibitor that functions to degrade intracellular polyubiquitinated… (More)
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2005
2005
AIM To study the distribution pattern of transcription factors NF-kappaB and AP-1 and their relations with the expression of… (More)
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Highly Cited
2002
Highly Cited
2002
DNA damage induced by the cancer chemotherapeutic drug etoposide triggers the onset of a series of intracellular events… (More)
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2002
2002
Continuous and long-lasting exposure to tert-butylhydroperoxide (t-BOOH) increased the number of apoptotic SH-SY5Y human… (More)
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1998
1998
PURPOSE To investigate whether the neurohormone melatonin can prevent apoptosis caused by deprivation of oxygen, glucose, and… (More)
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1997
1997
As part of the CASP2 protein structure prediction experiment, a set of numerical criteria were defined for the evaluation of "ab… (More)
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1996
1996
COS cells are resistant to cell death induced either by interleukin-1beta-converting enzyme (*ICE) and ICE homolog (ICH-1L… (More)
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Highly Cited
1994
Highly Cited
1994
We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the… (More)
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