Skip to search formSkip to main contentSkip to account menu

CASP2 protein, human

Known as: CASP-2, caspase 2, apoptosis-related cysteine protease protein, human, ICH1 
Caspase-2 (452 aa, ~51 kDa) is encoded by the human CASP2 gene. This protein is involved in cell cycle arrest, apoptosis and proteolysis.
National Institutes of Health

Related topics

Related topics

30 relations
ApoptosisBrainCASP2 geneCASP2 wt Allele

Broader (3)

Cysteine EndopeptidasesProteinscaspase-2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Caspase-2 as a tumour suppressor
Ever since its discovery 20 years ago, caspase-2 has been enigmatic and its function somewhat controversial. Although many in… 
Highly Cited
2013
Highly Cited
2013
Caspase-2 is required for dendritic spine and behavioral alterations in J20 APP transgenic mice
Caspases have critical roles in Alzheimer’s disease pathogenesis. Here we show that caspase-2 is required for the cognitive… 
Highly Cited
2004
Highly Cited
2004
Caspase-2 Permeabilizes the Outer Mitochondrial Membrane and Disrupts the Binding of Cytochrome c to Anionic Phospholipids*
Caspases are cysteine proteases that play a central role in the execution of apoptosis. Recent evidence indicates that caspase-2… 
2002
2002
Ca2+‐independent caspase‐3 but not Ca2+‐dependent caspase‐2 activation induced by oxidative stress leads to SH‐SY5Y human neuroblastoma cell apoptosis
Continuous and long‐lasting exposure to tert‐butylhydroperoxide (t‐BOOH) increased the number of apoptotic SH‐SY5Y human… 
Highly Cited
1998
Highly Cited
1998
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease
Highly Cited
1998
Highly Cited
1998
Dimerization and Autoprocessing of the Nedd2 (Caspase-2) Precursor Requires both the Prodomain and the Carboxyl-terminal Regions*
Nedd2 (caspase-2) is a cysteine protease of the caspase family that has been demonstrated to play a role in the apoptotic pathway… 
Highly Cited
1997
Highly Cited
1997
Characterization of seven murine caspase family members
Highly Cited
1997
Highly Cited
1997
Functional Activation of Nedd2/ICH-1 (Caspase-2) Is an Early Process in Apoptosis*
The ICE/CED-3 family of proteases (caspases) play a central role in the execution phase of apoptosis. These proteases are… 
Highly Cited
1996
Highly Cited
1996
Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis*
Apoptosis induced by a variety of agents results in the proteolytic cleavage of a number of cellular substrates by enzymes… 
Highly Cited
1996
Highly Cited
1996
Suppression of Interleukin-1-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor (*)
COS cells are resistant to cell death induced either by interleukin-1β-converting enzyme (*ICE) and ICE homolog (ICH-1… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)