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CASP2 protein, human

Known as: CASP-2, caspase 2, apoptosis-related cysteine protease protein, human, ICH1 
Caspase-2 (452 aa, ~51 kDa) is encoded by the human CASP2 gene. This protein is involved in cell cycle arrest, apoptosis and proteolysis.
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
The endoplasmic reticulum (ER) is the primary organelle for folding and maturation of secretory and transmembrane proteins… Expand
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Highly Cited
2004
Highly Cited
2004
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in… Expand
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Highly Cited
2002
Highly Cited
2002
Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced apoptosis remains unknown. We show… Expand
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Highly Cited
2002
Highly Cited
2002
The cysteine proteases specific for aspartic residues, known as caspases, are localized in different subcellular compartments and… Expand
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Highly Cited
1999
Highly Cited
1999
The barrier function of mitochondrial membranes is perturbed early during the apoptotic process. Here we show that the… Expand
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Highly Cited
1998
Highly Cited
1998
Apoptosis requires recruitment of caspases by receptor-associated adaptors through homophilic interactions between the CARDs… Expand
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Highly Cited
1998
Highly Cited
1998
During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of… Expand
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Highly Cited
1997
Highly Cited
1997
THE effector arm of the cell-death pathway is composed of cysteine proteases belonging to the ICE/CED-3 family1,2. In metazoan… Expand
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Highly Cited
1997
Highly Cited
1997
Seven members of the murine caspase (mCASP) family were cloned and functionally characterized by transient overexpression: mCASP… Expand
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Highly Cited
1994
Highly Cited
1994
We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the… Expand
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