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CASP2 protein, human

Known as: CASP-2, caspase 2, apoptosis-related cysteine protease protein, human, ICH1 
Caspase-2 (452 aa, ~51 kDa) is encoded by the human CASP2 gene. This protein is involved in cell cycle arrest, apoptosis and proteolysis.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
To Die For The unfolded protein response (UPR) adjusts the protein folding capacity of the endoplasmic reticulum (ER) to match… Expand
Highly Cited
2004
Highly Cited
2004
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in… Expand
Highly Cited
2002
Highly Cited
2002
Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced apoptosis remains unknown. We show… Expand
Highly Cited
2002
Highly Cited
2002
DNA damage induced by the cancer chemotherapeutic drug etoposide triggers the onset of a series of intracellular events… Expand
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Highly Cited
2000
Highly Cited
2000
Caspases are an extended family of cysteine proteases that play critical roles in apoptosis. Animals deficient in caspases-2 or… Expand
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Highly Cited
1999
Highly Cited
1999
The barrier function of mitochondrial membranes is perturbed early during the apoptotic process. Here we show that the… Expand
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Highly Cited
1998
Highly Cited
1998
During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of… Expand
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Highly Cited
1997
Highly Cited
1997
THE effector arm of the cell-death pathway is composed of cysteine proteases belonging to the ICE/CED-3 family1,2. In metazoan… Expand
Highly Cited
1994
Highly Cited
1994
We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the… Expand
Highly Cited
1994
Highly Cited
1994
By subtraction cloning we previously identified a set of mouse genes (named Nedd1 through Nedd10) with developmentally down… Expand