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CASP2 protein, human

Known as: CASP-2, caspase 2, apoptosis-related cysteine protease protein, human, ICH1 
Caspase-2 (452 aa, ~51 kDa) is encoded by the human CASP2 gene. This protein is involved in cell cycle arrest, apoptosis and proteolysis.
National Institutes of Health

Related topics

Related topics

30 relations
ApoptosisBrainCASP2 geneCASP2 wt Allele

Broader (3)

Cysteine EndopeptidasesProteinscaspase-2

Papers overview

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Highly Cited
2012
Highly Cited
2012
IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2
To Die For The unfolded protein response (UPR) adjusts the protein folding capacity of the endoplasmic reticulum (ER) to match… 
Highly Cited
2004
Highly Cited
2004
The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in… 
Highly Cited
2002
Highly Cited
2002
Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria*
Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced apoptosis remains unknown. We show… 
Highly Cited
2002
Highly Cited
2002
Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis*
DNA damage induced by the cancer chemotherapeutic drug etoposide triggers the onset of a series of intracellular events… 
Highly Cited
2000
Highly Cited
2000
Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis
Caspases are an extended family of cysteine proteases that play critical roles in apoptosis. Animals deficient in caspases-2 or… 
Highly Cited
1999
Highly Cited
1999
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
The barrier function of mitochondrial membranes is perturbed early during the apoptotic process. Here we show that the… 
Highly Cited
1998
Highly Cited
1998
Defects in regulation of apoptosis in caspase-2-deficient mice.
During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of… 
Highly Cited
1997
Highly Cited
1997
RAIDD is a new 'death' adaptor molecule
THE effector arm of the cell-death pathway is composed of cysteine proteases belonging to the ICE/CED-3 family1,2. In metazoan… 
Highly Cited
1994
Highly Cited
1994
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
Highly Cited
1994
Highly Cited
1994
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.
By subtraction cloning we previously identified a set of mouse genes (named Nedd1 through Nedd10) with developmentally down… 
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