CASP2 protein, human

The endoplasmic reticulum (ER) is the primary organelle for folding and maturation of secretory and transmembrane proteins… Expand

Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in… Expand

Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced apoptosis remains unknown. We show… Expand

The cysteine proteases specific for aspartic residues, known as caspases, are localized in different subcellular compartments and… Expand

The barrier function of mitochondrial membranes is perturbed early during the apoptotic process. Here we show that the… Expand

Apoptosis requires recruitment of caspases by receptor-associated adaptors through homophilic interactions between the CARDs… Expand

During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of… Expand

THE effector arm of the cell-death pathway is composed of cysteine proteases belonging to the ICE/CED-3 family1,2. In metazoan… Expand

Seven members of the murine caspase (mCASP) family were cloned and functionally characterized by transient overexpression: mCASP… Expand

We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the… Expand