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CASP2 protein, human
Known as:
CASP-2
, caspase 2, apoptosis-related cysteine protease protein, human
, ICH1
Â
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Caspase-2 (452 aa, ~51 kDa) is encoded by the human CASP2 gene. This protein is involved in cell cycle arrest, apoptosis and proteolysis.
National Institutes of Health
Topic mentions per year
Topic mentions per year
1994-2018
0
2
4
6
1994
2018
Related topics
Related topics
29 relations
Apoptosis
Brain
CASP2 gene
CASP2 wt Allele
(More)
Broader (3)
Cysteine Endopeptidases
Proteins
caspase-2
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
CASP2 protein, human
Hydrolysis
Brain
Apoptosis
Fetus
Liver
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Melissa Machado
,
Gioia Michelotti
,
+11 authors
A. Diehl
Gut
2015
OBJECTIVE Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific…Â
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2014
2014
A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.
Meenakshi Tiwari
,
Lokendra Kumar Sharma
,
+4 authors
B. Herman
Autophagy
2014
CASP2/caspase 2 plays a role in aging, neurodegeneration, and cancer. The contributions of CASP2 have been attributed to its…Â
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2006
2006
PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells.
Bonnie H. Y. Yeung
,
Der-Chen Huang
,
Frank A. Sinicrope
The Journal of biological chemistry
2006
PS-341 (bortezomib) is a potent and reversible proteosome inhibitor that functions to degrade intracellular polyubiquitinated…Â
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2005
2005
Activation of transcription factors NF-kappaB and AP-1 and their relations with apoptosis associated-proteins in hepatocellular carcinoma.
Lin-lang Guo
,
Sha Xiao
,
Ying Guo
World journal of gastroenterology
2005
AIM To study the distribution pattern of transcription factors NF-kappaB and AP-1 and their relations with the expression of…Â
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Highly Cited
2002
Highly Cited
2002
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis.
J. Douglas Robertson
,
Mari Enoksson
,
Minna Suomela
,
Boris Zhivotovsky
,
Sten Orrenius
The Journal of biological chemistry
2002
DNA damage induced by the cancer chemotherapeutic drug etoposide triggers the onset of a series of intracellular events…Â
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2002
2002
Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.
Salvatore M. Amoroso
,
Angela D'Alessio
,
Rossana Sirabella
,
Gianfranco F Di Renzo
,
Lucio Annunziato
Journal of neuroscience research
2002
Continuous and long-lasting exposure to tert-butylhydroperoxide (t-BOOH) increased the number of apoptotic SH-SY5Y human…Â
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1998
1998
Melatonin counteracts ischemia-induced apoptosis in human retinal pigment epithelial cells.
Nicholas Osborne
,
Micheal Nash
,
John M. Wood
Investigative ophthalmology & visual science
1998
PURPOSE To investigate whether the neurohormone melatonin can prevent apoptosis caused by deprivation of oxygen, glucose, and…Â
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1997
1997
Numerical criteria for the evaluation of ab initio predictions of protein structure.
Adam Zemla
,
ÄŒeslovas Venclovas
,
Adam L. Reinhardt
,
Kwasi Fidelis
,
T J Hubbard
Proteins
1997
As part of the CASP2 protein structure prediction experiment, a set of numerical criteria were defined for the evaluation of "ab…Â
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1996
1996
Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor.
Y. Jung
,
Masahiko Miura
,
J Yuan
The Journal of biological chemistry
1996
COS cells are resistant to cell death induced either by interleukin-1beta-converting enzyme (*ICE) and ICE homolog (ICH-1L…Â
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Highly Cited
1994
Highly Cited
1994
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.
Lang Wang
,
Masahiko Miura
,
Louis E. Bergeron
,
H. Zhu
,
J Yuan
Cell
1994
We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the…Â
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