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caspase-2

Known as: ICH-1 Protease, Caspase 2 [Chemical/Ingredient], Caspase 2 
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the… 
National Institutes of Health

Related topics

Related topics

19 relations
CASP2 geneCASP4 protein, humanIn BloodProcess of secretion

Narrower (2)

CASP2 protein, humanProcaspase-2

Broader (1)

Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity
The mechanism by which caspase‐2 executes apoptosis remains obscure. Recent findings indicate that caspase‐2 is activated early… 
2003
2003
A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells.
Both the anticancer agent 2-chloro-2'-deoxy-adenosine (Cladribine) and its derivative 2-chloro-adenosine induce apoptosis of… 
Review
2002
Review
2002
The Role of Pro‐ and Anti‐apoptotic Molecular Interactions in Embryonic Maldevelopment
Toder V, Carp H, Fein A, Torchinsky A. The role of pro‐ and anti‐apoptotic molecular interactions in embryonic maldevelopment… 
Highly Cited
2001
Highly Cited
2001
Polypyrimidine Track-binding Protein Binding Downstream of Caspase-2 Alternative Exon 9 Represses Its Inclusion*
We have been using the caspase-2 pre-mRNA as a model system to study the importance of alternative splicing in the regulation of… 
Highly Cited
2000
Highly Cited
2000
Mechanism of nitric oxide‐induced apoptosis in human neuroblastoma SH‐SY5Y cells
Highly Cited
2000
Highly Cited
2000
Genes with homology to mammalian apoptosis regulators identified in zebrafish
Programmed cell death (PCD) is an evolutionarily conserved mechanism of cellular demise developed by metazoans to delete cells… 
Highly Cited
1999
Highly Cited
1999
Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells.
Highly Cited
1999
Highly Cited
1999
Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C.
Activation of caspases is critical for the induction of apoptosis. We have shown previously that cell death mediated by the… 
1999
1999
Requirement of cooperative functions of two repeated death effector domains in caspase‐8 and in MC159 for induction and inhibition of apoptosis, respectively
The death effector domain (DED), which functions as a domain for a homophilic protein interaction, plays a role in death receptor… 
Highly Cited
1998
Highly Cited
1998
Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia
In rats, striatal histotoxic hypoxic lesions produced by the mitochondrial toxin malonate resemble those of focal cerebral… 
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