caspase-2

Known as: ICH-1 Protease, Caspase 2 [Chemical/Ingredient], Caspase 2 
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
0204019972017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Evasion of DNA damage-induced cell death, via mutation of the p53 tumor suppressor or overexpression of prosurvival Bcl-2 family… (More)
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Highly Cited
2004
Highly Cited
2004
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in… (More)
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Highly Cited
2002
Highly Cited
2002
Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced apoptosis remains unknown. We show… (More)
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Highly Cited
2002
Highly Cited
2002
A current view is that cytotoxic stress, such as DNA damage, induces apoptosis by regulating the permeability of mitochondria… (More)
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Highly Cited
2002
Highly Cited
2002
DNA damage induced by the cancer chemotherapeutic drug etoposide triggers the onset of a series of intracellular events… (More)
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Highly Cited
2000
Highly Cited
2000
beta-amyloid (Abeta) has been proposed to play a role in the pathogenesis of Alzheimer's disease (AD). Deposits of insoluble… (More)
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Highly Cited
2000
Highly Cited
2000
Caspases are an extended family of cysteine proteases that play critical roles in apoptosis. Animals deficient in caspases-2 or… (More)
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Highly Cited
1999
Highly Cited
1999
The barrier function of mitochondrial membranes is perturbed early during the apoptotic process. Here we show that the… (More)
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Highly Cited
1998
Highly Cited
1998
During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of… (More)
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Highly Cited
1998
Highly Cited
1998
Studies with peptide-based and macromolecular inhibitors of the caspase family of cysteine proteases have helped to define a… (More)
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