Skip to search formSkip to main contentSkip to account menu

caspase-2

Known as: ICH-1 Protease, Caspase 2 [Chemical/Ingredient], Caspase 2 
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the… 
National Institutes of Health

Related topics

Related topics

19 relations
CASP2 geneCASP4 protein, humanIn BloodProcess of secretion

Narrower (2)

CASP2 protein, humanProcaspase-2

Broader (1)

Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity
The mechanism by which caspase‐2 executes apoptosis remains obscure. Recent findings indicate that caspase‐2 is activated early… 
Highly Cited
2004
Highly Cited
2004
Caspase-2 and Caspase-7 Are Involved in Cytolethal Distending Toxin-Induced Apoptosis in Jurkat and MOLT-4 T-Cell Lines
ABSTRACT Cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans is a G2/M cell-cycle-specific growth… 
2003
2003
Caspase activation pathways induced by staurosporine and low potassium: Role of caspase‐2
Apoptotic death is a physiological process with regulatory mechanisms that are under the control of different molecules such as… 
Highly Cited
2002
Highly Cited
2002
Caspase activation and death induced by yessotoxin in HeLa cells.
Highly Cited
2001
Highly Cited
2001
Polypyrimidine Track-binding Protein Binding Downstream of Caspase-2 Alternative Exon 9 Represses Its Inclusion*
We have been using the caspase-2 pre-mRNA as a model system to study the importance of alternative splicing in the regulation of… 
Highly Cited
2001
Highly Cited
2001
Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells.
Highly Cited
2000
Highly Cited
2000
Mechanism of nitric oxide‐induced apoptosis in human neuroblastoma SH‐SY5Y cells
Highly Cited
1999
Highly Cited
1999
Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells.
Highly Cited
1998
Highly Cited
1998
Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia
In rats, striatal histotoxic hypoxic lesions produced by the mitochondrial toxin malonate resemble those of focal cerebral… 
Highly Cited
1998
Highly Cited
1998
Conversion of Procaspase-3 to an Autoactivating Caspase by Fusion to the Caspase-2 Prodomain*
Caspases are cysteine proteases that play an essential role in apoptosis. Initial activation of caspases defines the key step in… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)