• Publications
  • Influence
Calcium: Regulation of cell death: the calcium–apoptosis link
TLDR
This work has shown that cellular Ca2+ overload, or perturbation of intracellularCa2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death. Expand
Mitochondria, oxidative stress and cell death
TLDR
There is accumulating evidence supporting a direct link between mitochondria, oxidative stress and cell death. Expand
Mitochondrial oxidative stress: implications for cell death.
TLDR
These findings have placed the mitochondria in the focus of current cell death research and highlighted the importance of understanding the mechanisms behind mitochondrial regulation of apoptosis. Expand
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
TLDR
It is shown that glutamate can induce either early necrosis or delayed apoptosis in cultures of cerebellar granule cells, suggesting that mitochondrial function is a critical factor that determines the mode of neuronal death in excitotoxicity. Expand
Triggering and modulation of apoptosis by oxidative stress.
TLDR
This review will address some of the current paradigms for oxidative stress and apoptosis, and discuss the potential mechanisms by which oxidants can modulate the apoptotic pathway. Expand
Cytochrome c release from mitochondria proceeds by a two-step process
TLDR
The results indicate that the release of cytochrome c involves a distinct two-step process that is undermined when either step is compromised, and this mechanism also extends to conditions of mitochondrial permeability transition insofar as cy tochrome c release is significantly depressed when the electrostatic interaction between cyto Chrome c and cardiolipin remains intact. Expand
[4] Isolation and use of liver cells
TLDR
The presently available results suggest that isolated hepatocytes—and cell suspensions isolated from certain other target tissues—may be a useful model for drug toxicity studies in the future. Expand
Cell death mechanisms and their implications in toxicology.
TLDR
The cell death and phagocytosis regulatory networks offer a multitude of targets for toxic chemicals. Expand
Calcium-mediated mechanisms in chemically induced cell death.
TLDR
This chapter discusses one particular aspect of chemically induced cell death, i.e. the role of the calcium ion in the early development of damage, and summarizes current evidence for an association between a per­ turbation of intracellular Ca2+ homeostasis and cytotoxicity. Expand
...
1
2
3
4
5
...