CASP4 protein, human

Known as: CASP-4, caspase 4, apoptosis-related cysteine protease protein, human, ICH-2 protein, human 
Caspase-4 (377 aa, ~43 kDa) is encoded by the human CASP4 gene. This protein plays a role in both proteolysis and apoptosis.
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various… (More)
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Highly Cited
2014
Highly Cited
2014
The murine caspase-11 non-canonical inflammasome responds to various bacterial infections. Caspase-11 activation-induced… (More)
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Highly Cited
2011
Highly Cited
2011
Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-binding oligomerization domain (NOD)-like… (More)
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Highly Cited
2010
Highly Cited
2010
Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Abeta), which triggers a cellular stress… (More)
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Highly Cited
2005
Highly Cited
2005
Bortezomib (Velcade, formerly known as PS-341) is a boronic acid dipeptide derivative that is a selective and potent inhibitor of… (More)
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Highly Cited
2005
Highly Cited
2005
In alpha(1)-antitrypsin (alpha1AT) deficiency, a polymerogenic mutant form of the secretory glycoprotein alpha1AT, alpha1ATZ, is… (More)
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Highly Cited
2001
Highly Cited
2001
We describe here the results of our analysis of the comparative modeling predictions submitted to the fourth round of Critical… (More)
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Highly Cited
2001
Highly Cited
2001
Rosetta ab initio protein structure predictions in CASP4 were considerably more consistent and more accurate than previous ab… (More)
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Review
1998
Review
1998
At present, mammalian caspases comprise a group of at least 13 protease members which either generate mature pro-inflammatory… (More)
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Highly Cited
1998
Highly Cited
1998
Caspases are a family of cysteine proteases related to interleukin-1 converting enzyme (ICE) and represent the effector arm of… (More)
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