• Publications
  • Influence
Primary age-related tauopathy (PART): a common pathology associated with human aging
We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains withExpand
  • 689
  • 56
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and twoExpand
  • 1,389
  • 51
  • PDF
Primary care outcomes in patients treated by nurse practitioners or physicians: a randomized trial.
CONTEXT Studies have suggested that the quality of primary care delivered by nurse practitioners is equal to that of physicians. However, these studies did not measure nurse practitioner practicesExpand
  • 903
  • 29
  • PDF
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment.
Evidence suggests that Alzheimer disease (AD) begins as a disorder of synaptic function, caused in part by increased levels of amyloid beta-peptide 1-42 (Abeta42). Both synaptic and cognitiveExpand
  • 382
  • 27
  • PDF
Microtubule assembly in the absence of added nucleotides.
Microtubule assembly is enhanced by the addition of 1 M sucrose or 4 M glycerol to the reassembly mixture. Tubulin can be purified from guinea pig brain readily and in good yield by two cycles ofExpand
  • 1,719
  • 19
  • PDF
Astroglia in CNS injury
The astroglial response to CNS injury is considered in the context of neuron‐glial relationships. Although previous models suggested that astroglial cells present in “scars” impede axon regrowthExpand
  • 506
  • 15
Dendrite and dendritic spine alterations in alzheimer models
Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients. Multicolor DiOlistic labeling of the hippocampus has been undertaken whichExpand
  • 215
  • 15
Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid
β-amyloid (Aβ) has been proposed to play a role in the pathogenesis of Alzheimer's disease (AD). Deposits of insoluble Aβ are found in the brains of patients with AD and are one of the pathologicalExpand
  • 319
  • 13
Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis
Cerebellar granule neurons (CGNs) undergo apoptosis when deprived of depolarizing concentrations of KCl, but the underlying molecular mechanisms are not yet clear. Although caspases have beenExpand
  • 243
  • 13
  • PDF
β‐Amyloid‐induced neuronal apoptosis requires c‐Jun N‐terminal kinase activation
β‐Amyloid (Aβ) has been strongly implicated in the pathophysiology of Alzheimer's disease (AD), but the means by which the aggregated form of this molecule induces neuronal death have not been fullyExpand
  • 142
  • 11