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Interaction between ATM protein and c-Abl in response to DNA damage
The gene mutated in the autosomal recessive disorder ataxia telangiectasia (AT), designated ATM (for 'AT mutated'), is a member of a family of phosphatidylinositol-3-kinase-like enzymes that areExpand
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Approaches to Learning by Students in the Biological Sciences: Implications for teaching
This study is an investigation of the epistemological beliefs and study habits of students undertaking first‐year courses in Biological Chemistry and Biochemistry. In particular, we were interestedExpand
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Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants.
BACKGROUND A recent in vitro model of oxidative stress-induced renal fibrosis demonstrated that activated or phosphorylated extracellular signal-regulated protein kinase (pERK) played a role inExpand
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Oxidative Stress Is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice
Atm gene-disrupted mice recapitulate the majority of characteristics observed in patients with the genetic disorder ataxia-telangiectasia (A-T). However, although they exhibit defects in neuromotorExpand
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PKC-delta is an apoptotic lamin kinase.
Protein kinase C-delta is activated during apoptosis, following proteolytic cleavage by caspase 3. Furthermore, overexpression of the catalytic kinase fragment of PKC-delta induces the nuclearExpand
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Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis*
Apoptosis induced by a variety of agents results in the proteolytic cleavage of a number of cellular substrates by enzymes related to interleukin 1β-converting enzyme (ICE). A small number ofExpand
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Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
  • N. Zhang, P. Chen, +7 authors M. Lavin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 22 July 1997
A gene mutated in the human genetic disorder ataxia-telangiectasia (A-T), ATM, was recently identified by positional cloning. ATM is a member of the phosphatidylinositol-3-kinase superfamily, some ofExpand
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ATM protein synthesis patterns in sporadic breast cancer.
AIMS: The gene mutated in ataxia-telangiectasia (A-T), designated ATM (for "A-T mutated"), is believed to be associated with an increased risk of developing breast cancer. Most patients with A-T haveExpand
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Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis*
The onset of apoptosis is coupled to the proteolytic activation of a family of cysteine proteases, termed caspases. These proteases cleave their target proteins after an aspartate residue. FollowingExpand
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Ototoxicity associated with use of nucleoside analog reverse transcriptase inhibitors: a report of 3 possible cases and review of the literature.
Although a variety of adverse effects have been attributed to treatment with nucleoside analog reverse transcriptase inhibitors (NRTIs) for human immunodeficiency virus type 1 (HIV-1) infection, onlyExpand
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