D. Watters

Publications68
h-index22
Citations2,358
Highly Influential Citations61
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Interaction between ATM protein and c-Abl in response to DNA damage
The gene mutated in the autosomal recessive disorder ataxia telangiectasia (AT), designated ATM (for 'AT mutated'), is a member of a family of phosphatidylinositol-3-kinase-like enzymes that are… Expand
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Approaches to Learning by Students in the Biological Sciences: Implications for teaching
This study is an investigation of the epistemological beliefs and study habits of students undertaking first‐year courses in Biological Chemistry and Biochemistry. In particular, we were interested… Expand
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Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants.
BACKGROUND A recent in vitro model of oxidative stress-induced renal fibrosis demonstrated that activated or phosphorylated extracellular signal-regulated protein kinase (pERK) played a role in… Expand
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Oxidative Stress Is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice
Atm gene-disrupted mice recapitulate the majority of characteristics observed in patients with the genetic disorder ataxia-telangiectasia (A-T). However, although they exhibit defects in neuromotor… Expand
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PKC-delta is an apoptotic lamin kinase.
Protein kinase C-delta is activated during apoptosis, following proteolytic cleavage by caspase 3. Furthermore, overexpression of the catalytic kinase fragment of PKC-delta induces the nuclear… Expand
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Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis*
Apoptosis induced by a variety of agents results in the proteolytic cleavage of a number of cellular substrates by enzymes related to interleukin 1β-converting enzyme (ICE). A small number of… Expand
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Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
  • N. Zhang, P. Chen, +7 authors M. Lavin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 22 July 1997
A gene mutated in the human genetic disorder ataxia-telangiectasia (A-T), ATM, was recently identified by positional cloning. ATM is a member of the phosphatidylinositol-3-kinase superfamily, some of… Expand
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ATM protein synthesis patterns in sporadic breast cancer.
AIMS: The gene mutated in ataxia-telangiectasia (A-T), designated ATM (for "A-T mutated"), is believed to be associated with an increased risk of developing breast cancer. Most patients with A-T have… Expand
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Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis*
The onset of apoptosis is coupled to the proteolytic activation of a family of cysteine proteases, termed caspases. These proteases cleave their target proteins after an aspartate residue. Following… Expand
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Ototoxicity associated with use of nucleoside analog reverse transcriptase inhibitors: a report of 3 possible cases and review of the literature.
Although a variety of adverse effects have been attributed to treatment with nucleoside analog reverse transcriptase inhibitors (NRTIs) for human immunodeficiency virus type 1 (HIV-1) infection, only… Expand
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