• Publications
  • Influence
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
TLDR
A large number of the subjects studied had previously been diagnosed with central giant cell granuloma, a type of cancer which can be difficult to treat with conventional chemotherapy.
Molecular mechanisms of necroptosis: an ordered cellular explosion
TLDR
Evidence now reveals that necrosis can also occur in a regulated manner, and necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.
Immunogenic cell death and DAMPs in cancer therapy
TLDR
The role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD are discussed.
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
TLDR
A functional classification of cell death subroutines is proposed that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic programmed cell death, regulated necrosis, autophagic cell death and mitotic catastrophe.
Necroptosis and its role in inflammation
TLDR
The mechanisms regulating necroptosis and its potential role in inflammation and disease are discussed and RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroPTosis and apoptosis.
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
TLDR
Elucidating how these pathways of regulated necrosis are interconnected at the molecular level should enable this process to be therapeutically targeted.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
TLDR
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
TLDR
A critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1 is revealed and insights regarding the pathogenesis of autoinflammatory syndromes are provided.
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
Gram-negative bacteria that replicate in the cytosol of mammalian macrophages can activate a signaling pathway leading to caspase-1 cleavage and secretion of interleukin 1β, a powerful host response
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
TLDR
A nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantages and pitfalls is provided and the importance of performing multiple, methodologically unrelated assays to quantify dying and dead cells is emphasized.
...
...