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C3 gene

Known as: CPAMD1, ACYLATION-STIMULATING PROTEIN, C3 
This gene plays a regulatory role in the complement pathway, which is comprised of a complex proteolytic cascade.
National Institutes of Health

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Related topics

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C3 DEFICIENCYCOMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVEComplement 3Complement Activation

Papers overview

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1985
1985
Angiography and complement activation. Evidence for generation of C3a anaphylatoxin by intravascular contrast agents.
The potent anaphylatoxin C3a was measured in the peripheral blood of eleven patients receiving radiocontrast agents whilst… 
1985
1985
Human C3a-mediated suppression of the immune response. I. Suppression of murine in vitro antibody responses occurs through the generation of nonspecific Lyt-2+ suppressor T cell.
C3a derived from the third component of human complement was found to suppress in vitro murine anti-SRBC responses. C3a-mediated… 
1984
1984
Active site of C3a anaphylatoxin: contributions of the lipophilic and orienting residues.
Activation of the serum complement cascade generates C3a anaphylatoxin, a primary mediator of inflammation. The active-site… 
1982
1982
Modulation of the immune response by anaphylatoxin in the microenvironment of the interacting cells.
It was shown that the anaphylatoxins C3a and C5a can modulate in vitro immunological reactivities. C3a suppresses both the in… 
1982
1982
C3a-induced lysosomal enzyme secretion from human neutrophils: lack of inhibition by f met-leu-phe antagonists and inhibition by arachidonic acid antagonists.
C3a-induced lysosomal enzyme secretion from human peripheral neutrophils in a noncytolytic, dose-dependent (10-100 microgram/ml… 
1981
1981
Complement activation requirements for histamine release from human leukocytes: influence of purified C3ahu and C5ahu on histamine release.
The activation of human sera for histamine release by zymosan and anti-BSA-BSA complexes at equivalence was dose dependent and… 
1980
1980
Aggregation of leukocytes induced by the complement-derived peptides C3a and C5a and by three synthetic formyl-methionyl peptides.
The highly purified hog complement peptides C3a and C5a and three formylmethionyl peptides induced dose-dependent aggregation of… 
1979
1979
Inhibition of lymphocyte blastogenesis by C3c and C3d.
The C3 cleavage products C3c and C3d were tested for their ability to alter the immunoproliferative response of human peripheral… 
1979
1979
Uptake of 125I-labelled C3a by cultured human endothelial cells.
The interactions of C3a anaphylatoxin with vascular endothelium were studied in vitro using human endothelial cells in culture… 
1978
1978
Macrophage secretion and the complement cleavage product C3a in the pathogenesis of infections by mycoplasmas and L-forms of bacteria and in immunity to these organisms.
Mouse peritoneal macrophages in culture exposed to Mycoplasma pulmonis show marked biochemical changes. This micro-organism…