Skip to search formSkip to main contentSkip to account menu

C3 gene

Known as: CPAMD1, ACYLATION-STIMULATING PROTEIN, C3 
This gene plays a regulatory role in the complement pathway, which is comprised of a complex proteolytic cascade.
National Institutes of Health

Related topics

Related topics

9 relations
C3 DEFICIENCYCOMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVEComplement 3Complement Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1987
1987
Anaphylatoxin-induced neutrophil chemotaxis and aggregation. Limited aggregation and specific desensitization induced by human C3a and synthetic C3a octapeptides.
Human neutrophil aggregation was induced by highly purified human C3a and chemically synthetic COOH-terminal peptides of C3a (C3a… 
1986
1986
Helical conformation at the carboxy-terminal portion of human C3a is required for full activity.
Human C3a, a 77-residue fragment released during complement activation, is a potent spasmogen that contracts smooth muscle… 
1985
1985
Angiography and complement activation. Evidence for generation of C3a anaphylatoxin by intravascular contrast agents.
The potent anaphylatoxin C3a was measured in the peripheral blood of eleven patients receiving radiocontrast agents whilst… 
1985
1985
Proton nuclear magnetic resonance study of the third component of complement: solution conformation of the carboxyl-terminal segment of C3a fragment.
A proton nuclear magnetic resonance (NMR) study is reported of des-Arg-C3a, which is a 76-residue fragment obtained from the N… 
1984
1984
Active site of C3a anaphylatoxin: contributions of the lipophilic and orienting residues.
Activation of the serum complement cascade generates C3a anaphylatoxin, a primary mediator of inflammation. The active-site… 
1982
1982
Modulation of the immune response by anaphylatoxin in the microenvironment of the interacting cells.
It was shown that the anaphylatoxins C3a and C5a can modulate in vitro immunological reactivities. C3a suppresses both the in… 
1980
1980
Aggregation of leukocytes induced by the complement-derived peptides C3a and C5a and by three synthetic formyl-methionyl peptides.
The highly purified hog complement peptides C3a and C5a and three formylmethionyl peptides induced dose-dependent aggregation of… 
1979
1979
Uptake of 125I-labelled C3a by cultured human endothelial cells.
The interactions of C3a anaphylatoxin with vascular endothelium were studied in vitro using human endothelial cells in culture… 
1978
1978
Macrophage secretion and the complement cleavage product C3a in the pathogenesis of infections by mycoplasmas and L-forms of bacteria and in immunity to these organisms.
Mouse peritoneal macrophages in culture exposed to Mycoplasma pulmonis show marked biochemical changes. This micro-organism… 
1975
1975
Cleavage of the third complement component (C3) and generation of the spasmogenic peptide, C3a, in human serum via the properdin pathway: demonstration of inhibitory as well as enhancing effects of…
Human and guinea pig serum loses hemolytic activity of the third complement component (C3) during incubation at 37 degrees C. The…