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C3 gene

Known as: CPAMD1, ACYLATION-STIMULATING PROTEIN, C3 
This gene plays a regulatory role in the complement pathway, which is comprised of a complex proteolytic cascade.
National Institutes of Health

Related topics

Related topics

9 relations
C3 DEFICIENCYCOMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVEComplement 3Complement Activation

Papers overview

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Highly Cited
2000
Highly Cited
2000
Acute vascular rejection is associated with systemic complement activation ina pig‐to‐primate kidney xenograft model
Abstract: The introduction of h‐DAF transgenic porcine organs into pre‐clinical pig‐to‐primate discordant xenotransplantation has… 
Highly Cited
1996
Highly Cited
1996
Expression of high‐ and low‐affinity receptors for C3a on the human mast cell line, HMC‐1
The proteolytic cleavage product of complement component 3, (C3a), like C4a and C5a, is a potent anaphylatoxin and induces the… 
Highly Cited
1994
Highly Cited
1994
C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins.
In contrast to C5a, which represents a well-established potent activator of the respiratory burst in polymorphonuclear… 
Highly Cited
1989
Highly Cited
1989
Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica.
The major secreted proteinase of Entamoeba histolytica, a 56-kDa neutral cysteine proteinase, activates C by cleaving C3. The… 
Highly Cited
1988
Highly Cited
1988
Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension.
Review
1984
Review
1984
Structure and function of the anaphylatoxins.
Chemical and physical characterization of the anaphylatoxin molecules have provided a reasonably clear description of the… 
Highly Cited
1983
Highly Cited
1983
Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase.
Tryptase, the dominant neutral protease of human pulmonary mast cell secretory granules, has the capacity in vitro to generate… 
Highly Cited
1982
Highly Cited
1982
Anaphylatoxin-mediated regulation of the immune response. I. C3a- mediated suppression of human and murine humoral immune responses
The C3a fragment of the third component of complement was found to have immunosuppressive properties. C3a is capable of… 
Highly Cited
1978
Highly Cited
1978
Production of the complement cleavage product, C3a, by activated macrophages and its tumorolytic effects.
Mouse peritoneal macrophages were activated in serum-free culture with lipopolysaccharide, dextran sulphate or C3b. They were… 
Highly Cited
1976
Highly Cited
1976
Partial characterization of human C5a anaphylatoxin. I. Chemical description of the carbohydrate and polypeptide prtions of human C5a.
Human C5a was isolated from complement-activated serum and was characterized for protein and carbohydrate content. The purified… 
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