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Patterns of cytokine gene expression by CD4+ T cells from young and old mice.
The data suggest that gradual age-associated shifts in the subset composition of the splenic CD4+ cell pool underlie progressive changes in the patterns of cytokine gene expression by this cell group. Expand
Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from
The CD4 T-helper and CD8 T-cell defects in B−/− mice suggest that B cells contribute to the induction of competent T effector cells. Expand
Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.
The expression patterns of subset determinants, in conjunction with cytokine secretion profiles, indicate that, in aged mice, marked alterations occur in the subset composition of the splenic CD4+ cell pool. Expand
The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.
The hypothesis that aging is accompanied by dramatic shifts in the subset compositions of splenic CD8+ cell pools, which contribute significantly to their increased capacity to produce IFN-gamma at the population level is supported. Expand
The cellular and subcellular bases of immunosenescence.
This chapter focuses on the cellular and intracellular basis for impaired immunologic activity, and the mucosal immune system provides evidence that not all lymphoid tissues are equally adversely affected by age. Expand
Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities.
It was found that LPS did not function as an adjuvant in C3H/HeJ mice, a unique strain whose spleen cells were also unresponsive to LPS-induced mitogenesis, and a correlation was also observed between mitogenesis and the capacity of LPS to function as a specific immunogen i mice. Expand
Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells
Both thymus and bone marrow cells of adult mice can be made specifically unresponsive to human gamma globulin, but each cell population displays a distinct kinetic pattern for both the induction andExpand
Cellular sites of immunologic unresponsiveness.
The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells, but neither bone marrow nor thymUS cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart. Expand
Metabolism and mammary secretion of serum proteins in the cow.