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C3 DEFICIENCY

A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the third… Expand
National Institutes of Health

Related topics

Related topics

3 relations
C3 geneComplement Factor I (C3 inactivator) deficiencyComplement deficiency

Papers overview

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Highly Cited
2017
Highly Cited
2017
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant A… Expand
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2014
2014
Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation.
Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are… Expand
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Highly Cited
2005
Highly Cited
2005
Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.
Our aim was to study whether the absence of apolipoprotein (apo) C3, a strong inhibitor of lipoprotein lipase (LPL), accelerates… Expand
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2005
2005
Complement component deficiencies and infection: C5, C8 and C3 deficiencies in three families
Three families are described with complement component deficiencies. In one family, five children had C5 deficiency; in a second… Expand
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2005
2005
Molecular analysis of a novel hereditary C3 deficiency with systemic lupus erythematosus.
A case of inherited homozygous complement C3 deficiency (C3D) in a patient with systemic lupus erythematosus (SLE) and the… Expand
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Highly Cited
2002
Highly Cited
2002
Influence of C3 Deficiency on Atherosclerosis
Background—The influence of complement activation on atherosclerosis is not well understood. The purpose of this study was to… Expand
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1994
1994
Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion.
We recently described a case of hereditary complement C3 deficiency (C3D) in a New Zealand male who has a small amount of serum… Expand
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Review
1994
Review
1994
Complement C3 deficiency: human, animal, and experimental models.
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface… Expand
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Review
1993
Review
1993
Hereditary deficiency of C3 in animals and humans.
Inherited deficiency of complement C3 has been described in guinea pigs, dogs and 20 humans. Homozygous deficiency of C3 is… Expand
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1988
1988
Inherited C3 deficiency with recurrent infections and glomerulonephritis.
A 10-year-old Laotian boy had homozygous deficiency of the third component of complement and recurrent bacterial infections… Expand
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