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C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant A… Expand Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are… Expand Our aim was to study whether the absence of apolipoprotein (apo) C3, a strong inhibitor of lipoprotein lipase (LPL), accelerates… Expand Abstract: Although frequently asymptomatic, homozygous C2 deficiency (C2D) is known to be associated with severe infections and… Expand Background—The influence of complement activation on atherosclerosis is not well understood. The purpose of this study was to… Expand The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface… Expand We recently described a case of hereditary complement C3 deficiency (C3D) in a New Zealand male who has a small amount of serum… Expand Inherited deficiency of complement C3 has been described in guinea pigs, dogs and 20 humans. Homozygous deficiency of C3 is… Expand A 10-year-old Laotian boy had homozygous deficiency of the third component of complement and recurrent bacterial infections… Expand Abstract A 5 10 12 - year-old girl with recurrent infections was found to have homozygous C3 deficiency. Family studies… Expand