FAQ

C3 DEFICIENCY

A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the third… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
012319752017

Related topics

Related topics

2 relations
C3 geneComplement deficiency

Related mentions per year

Related mentions per year

1961-2018
1960198020002020
C3 DEFICIENCY
C3 gene
Complement deficiency

Papers overview

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2017
2017
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.
The complement cascade not only is an innate immune response that enables removal of pathogens but also plays an important role… (More)
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2014
2014
Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation.
Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are… (More)
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2011
2011
Complement C3 deficiency prevent against the onset of streptozotocin-induced autoimmune diabetes involving expansion of regulatory T cells.
Recent studies have demonstrated that complement contributes to the development of autoimmune diabetes. However, the mechanisms… (More)
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2005
2005
Molecular analysis of a novel hereditary C3 deficiency with systemic lupus erythematosus.
A case of inherited homozygous complement C3 deficiency (C3D) in a patient with systemic lupus erythematosus (SLE) and the… (More)
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2002
2002
Homozygous Hereditary C3 Deficiency Due to a Premature Stop Codon
C3 deficiency in humans is a rare disorder characterized by severe recurrent infections. We identified the mutations responsible… (More)
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2002
2002
Recurrent pneumococcal meningitis in homozygous C3 deficiency.
Congenital deficiencies of complement system proteins are rare. A 4-year-old girl was admitted for meningitis. She had had… (More)
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1992
1992
Complement component deficiencies and infection: C5, C8 and C3 deficiencies in three families
Three families are described with complement component deficiencies. In one family, five children had C5 deficiency; in a second… (More)
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1990
1990
Molecular basis of complement C3 deficiency in guinea pigs.
In experiments to ascertain the biochemical basis of a genetically determined deficiency of the third component of complement (C3… (More)
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1988
1988
Inherited C3 deficiency with recurrent infections and glomerulonephritis.
A 10-year-old Laotian boy had homozygous deficiency of the third component of complement and recurrent bacterial infections… (More)
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1986
1986
Impaired humoral immune response in complement C3-deficient guinea pigs: absence of secondary antibody response.
A recently described genetically controlled C3 deficiency (C3D) in guinea pigs (GP) provided a unique model for studying the role… (More)
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