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C3 DEFICIENCY

A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the third… Expand
National Institutes of Health

Related topics

Related topics

3 relations
C3 geneComplement Factor I (C3 inactivator) deficiencyComplement deficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant A… Expand
Highly Cited
2014
Highly Cited
2014
Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation.
Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are… Expand
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Highly Cited
2005
Highly Cited
2005
Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.
Our aim was to study whether the absence of apolipoprotein (apo) C3, a strong inhibitor of lipoprotein lipase (LPL), accelerates… Expand
Review
2005
Review
2005
Hereditary C2 Deficiency in Sweden: Frequent Occurrence of Invasive Infection, Atherosclerosis, and Rheumatic Disease
Abstract: Although frequently asymptomatic, homozygous C2 deficiency (C2D) is known to be associated with severe infections and… Expand
Highly Cited
2002
Highly Cited
2002
Influence of C3 Deficiency on Atherosclerosis
Background—The influence of complement activation on atherosclerosis is not well understood. The purpose of this study was to… Expand
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Review
1994
Review
1994
Complement C3 deficiency: human, animal, and experimental models.
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface… Expand
1994
1994
Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion.
We recently described a case of hereditary complement C3 deficiency (C3D) in a New Zealand male who has a small amount of serum… Expand
Review
1993
Review
1993
Hereditary deficiency of C3 in animals and humans.
Inherited deficiency of complement C3 has been described in guinea pigs, dogs and 20 humans. Homozygous deficiency of C3 is… Expand
1988
1988
Inherited C3 deficiency with recurrent infections and glomerulonephritis.
A 10-year-old Laotian boy had homozygous deficiency of the third component of complement and recurrent bacterial infections… Expand
1977
1977
Homozygous C3 deficiency: detection of C3 by radioimmunoassay.
Abstract A 5 10 12 - year-old girl with recurrent infections was found to have homozygous C3 deficiency. Family studies… Expand
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