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C3 DEFICIENCY

A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the third… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant A… Expand
Highly Cited
2014
Highly Cited
2014
Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are… Expand
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Highly Cited
2005
Highly Cited
2005
Our aim was to study whether the absence of apolipoprotein (apo) C3, a strong inhibitor of lipoprotein lipase (LPL), accelerates… Expand
Review
2005
Review
2005
Abstract: Although frequently asymptomatic, homozygous C2 deficiency (C2D) is known to be associated with severe infections and… Expand
Highly Cited
2002
Highly Cited
2002
Background—The influence of complement activation on atherosclerosis is not well understood. The purpose of this study was to… Expand
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Review
1994
Review
1994
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface… Expand
1994
1994
We recently described a case of hereditary complement C3 deficiency (C3D) in a New Zealand male who has a small amount of serum… Expand
Review
1993
Review
1993
Inherited deficiency of complement C3 has been described in guinea pigs, dogs and 20 humans. Homozygous deficiency of C3 is… Expand
1988
1988
A 10-year-old Laotian boy had homozygous deficiency of the third component of complement and recurrent bacterial infections… Expand
1977
1977
Abstract A 5 10 12 - year-old girl with recurrent infections was found to have homozygous C3 deficiency. Family studies… Expand