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C3 DEFICIENCY

A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the third… 
National Institutes of Health

Related topics

Related topics

3 relations
C3 geneComplement Factor I (C3 inactivator) deficiencyComplement deficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant A… 
Highly Cited
2005
Highly Cited
2005
Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.
Our aim was to study whether the absence of apolipoprotein (apo) C3, a strong inhibitor of lipoprotein lipase (LPL), accelerates… 
Review
2005
Review
2005
Hereditary C2 Deficiency in Sweden: Frequent Occurrence of Invasive Infection, Atherosclerosis, and Rheumatic Disease
Abstract: Although frequently asymptomatic, homozygous C2 deficiency (C2D) is known to be associated with severe infections and… 
2005
2005
Complement component deficiencies and infection: C5, C8 and C3 deficiencies in three families
Three families are described with complement component deficiencies. In one family, five children had C5 deficiency; in a second… 
Highly Cited
2002
Highly Cited
2002
Influence of C3 Deficiency on Atherosclerosis
Background—The influence of complement activation on atherosclerosis is not well understood. The purpose of this study was to… 
1998
1998
Molecular analysis of the third component of canine complement (C3) and identification of the mutation responsible for hereditary canine C3 deficiency.
Genetically determined deficiency of the third component of complement (C3) in the dog is characterized by a predisposition to… 
Review
1994
Review
1994
Complement C3 deficiency: human, animal, and experimental models.
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface… 
Review
1993
Review
1993
Hereditary deficiency of C3 in animals and humans.
Inherited deficiency of complement C3 has been described in guinea pigs, dogs and 20 humans. Homozygous deficiency of C3 is… 
1988
1988
Inherited C3 deficiency with recurrent infections and glomerulonephritis.
A 10-year-old Laotian boy had homozygous deficiency of the third component of complement and recurrent bacterial infections… 
Highly Cited
1986
Highly Cited
1986
Impaired humoral immune response in complement C3‐deficient guinea pigs: absence of secondary antibody response
A recently described egenetically controlled C3 deficiency (C3D) in guinea pigs (GP) provided a unique model for studying the… 
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