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C3 DEFICIENCY

A rare genetic disorder with an autosomal recessive pattern of inheritance. It is caused by the ineffective or decreased biosynthesis of the third… 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant A… 
Highly Cited
2005
Highly Cited
2005
Our aim was to study whether the absence of apolipoprotein (apo) C3, a strong inhibitor of lipoprotein lipase (LPL), accelerates… 
Review
2005
Review
2005
Abstract: Although frequently asymptomatic, homozygous C2 deficiency (C2D) is known to be associated with severe infections and… 
2005
2005
Three families are described with complement component deficiencies. In one family, five children had C5 deficiency; in a second… 
Highly Cited
2002
Highly Cited
2002
Background—The influence of complement activation on atherosclerosis is not well understood. The purpose of this study was to… 
1998
1998
Genetically determined deficiency of the third component of complement (C3) in the dog is characterized by a predisposition to… 
Review
1994
Review
1994
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface… 
Review
1993
Review
1993
Inherited deficiency of complement C3 has been described in guinea pigs, dogs and 20 humans. Homozygous deficiency of C3 is… 
1988
1988
A 10-year-old Laotian boy had homozygous deficiency of the third component of complement and recurrent bacterial infections… 
Highly Cited
1986
Highly Cited
1986
A recently described egenetically controlled C3 deficiency (C3D) in guinea pigs (GP) provided a unique model for studying the…