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The Instructive Role of Innate Immunity in the Acquired Immune Response
Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may haveExpand
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Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
Significance Cancer immune evasion is well described. In some cases, this may be overcome by enhancing T-cell responses. We show that despite the presence of antitumor T cells, immunotherapeuticExpand
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C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity
An optimal immune response should differentiate between harmful and innocuous antigens. Primitive systems of innate immunity, such as the complement system, may play a role in this distinction. WhenExpand
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Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis.
The complement system is an important mediator of the acute inflammatory response, and an effective inhibitor would suppress tissue damage in many autoimmune and inflammatory diseases. Such anExpand
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T cell exclusion, immune privilege, and the tumor microenvironment
Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific T cells be generated, but also that these T cells physically contactExpand
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Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex.
The membrane protein complex CD19/CD21 couples the innate immune recognition of microbial antigens by the complement system to the activation of B cells. CD21 binds the C3d fragment of activated C3Expand
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Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α
Tumor Vaccination Success Vaccination with tumor-specific antigens is one of several attempted therapies seeking to harness the immune system, but—unfortunately—this strategy has been unsuccessful,Expand
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Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.
Identity of the Epstein-Barr virus (EBV) receptor with the complement receptor type 2 (CR2) was established in three sets of experiments using the monoclonal antibodies, HB-5 and anti-B2, whichExpand
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CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.
Antigen receptors on B and T lymphocytes transduce signals by activating nonreceptor protein tyrosine kinases (PTKs). A family of receptor PTKs contains kinase insert regions with the sequenceExpand
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Identifying genes important for spermatogonial stem cell self-renewal and survival.
Spermatogonial stem cells (SSCs) are the foundation for spermatogenesis and, thus, preservation of a species. Because of stem cell rarity, studying their self-renewal is greatly facilitated by inExpand
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