• Publications
  • Influence
Mycophenolate mofetil and its mechanisms of action.
TLDR
The efficacy of regimes including CellCept(R) in preventing allograft rejection, and in the treatment of rejection, is now firmly established and it is hoped that the drug will have the same effect in humans. Expand
Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection
  • A. Allison
  • Medicine
  • British medical journal
  • 6 February 1954
In view of the regional differences in sensitivity found in the earlier experiments one would expect that the units responding, for exampk, to acetone would be found more often in the front part ofExpand
Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
TLDR
It is proposed that oncogene-containing tumor cell-derived MVs could act as a unique form of angiogenesis-modulating stimuli and are capable of switching endothelial cells to act in an autocrine mode. Expand
Immunosuppressive drugs: the first 50 years and a glance forward.
  • A. Allison
  • Biology, Medicine
  • Immunopharmacology
  • 1 May 2000
TLDR
A promising future application of immunosuppressive drugs is their use in a regime to induce tolerance to allografts, and the induction of apoptosis of clones of responding T-lymphocytes, is discussed. Expand
Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection.
TLDR
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), an inhibitor of inosine-5'-monophosphate dehydrogenase, has several immunosuppressant actions and may prevent chronic rejection by several mechanisms. Expand
Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.
  • S. Lee, A. Tsou, +4 authors A. Allison
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 February 1988
TLDR
Inhibition of the formation and effects IL-1 is a mechanism by which glucocorticoids can exert antiinflammatory and immunosuppressive effects and kinetic analyses and pulse-labeling of mRNAs showed that glucoc Corticoids selectively decrease the stability of IL- 1 beta mRNA, without affecting the stabilityof beta-actin and FOS mRN as. Expand
Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia
TLDR
It is suggested that cachectin/TNF is essential for the initiation or amplification of IL-1 and IL-6 release during lethal gram-negative septic shock syndrome. Expand
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease
TLDR
The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD. Expand
The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria.
  • A. Allison
  • Biology, Medicine
  • Transactions of the Royal Society of Tropical…
  • 1 July 1954
TLDR
The incidence of the sickle-cell trait in any population appears to be the result of a balance between at least two factors: the severity of malaria, which will tend to increase the frequency of the trait, and the rate of elimination of sickle cell genes in subjects dying of Sickle- cell anaemia. Expand
Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF).
TLDR
Clinically attainable concentrations of MPA suppress the proliferation of human arterial smooth muscle cells and may decrease the risk of lymphoma development and proliferative arteriopathy in long-term recipients of MMF. Expand
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