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Mycophenolate mofetil and its mechanisms of action.
Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection
- A. Allison
- EducationBritish medical journal
- 6 February 1954
In view of the regional differences in sensitivity found in the earlier experiments one would expect that the units responding, for exampk, to acetone would be found more often in the front part of…
Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
- K. Al-Nedawi, B. Meehan, R. Kerbel, A. Allison, J. Rak
- BiologyProceedings of the National Academy of Sciences
- 10 March 2009
It is proposed that oncogene-containing tumor cell-derived MVs could act as a unique form of angiogenesis-modulating stimuli and are capable of switching endothelial cells to act in an autocrine mode.
Immunosuppressive drugs: the first 50 years and a glance forward.
- A. Allison
- Biology, ChemistryImmunopharmacology
- 1 May 2000
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease
Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection.
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), an inhibitor of inosine-5'-monophosphate dehydrogenase, has several immunosuppressant actions and may prevent chronic rejection by several mechanisms.
Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.
- S. Lee, A. Tsou, A. Allison
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 February 1988
Inhibition of the formation and effects IL-1 is a mechanism by which glucocorticoids can exert antiinflammatory and immunosuppressive effects and kinetic analyses and pulse-labeling of mRNAs showed that glucoc Corticoids selectively decrease the stability of IL- 1 beta mRNA, without affecting the stabilityof beta-actin and FOS mRN as.
Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia
It is suggested that cachectin/TNF is essential for the initiation or amplification of IL-1 and IL-6 release during lethal gram-negative septic shock syndrome.
Immunosuppressive and other Effects of Mycophenolic Acid and an Ester Prodrug, Mycophenolate Mofetil
The advantages and limitations of currently used immunosuppressive drugs are well known; for example, cyclophosphamide can produce hemorrhagic cystitis and cyclosporin can cause nephrotoxicity and hypertension; and methotrexate may lead to liver damage, pneumonitis and bone marrow suppression.
POLYMORPHISM AND NATURAL SELECTION IN HUMAN POPULATIONS.
- A. Allison
- BiologyCold Spring Harbor Symposia on Quantitative…