Bumetanide

Known as: 3-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid, Bumetanidum, 3-Butylamino-4-phenoxy-5-sulfamoyl-benzoic acid 
A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting… (More)
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Highly Cited
2010
Highly Cited
2010
Accumulating evidence suggests that changes in neuronal chloride homeostasis may be involved in the mechanisms by which brain… (More)
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2009
2009
PURPOSE To examine the effects of bumetanide, a selective blocker of Na+-K+-2Cl- cotransporter (NKCC1), on hippocampal… (More)
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Highly Cited
2007
Highly Cited
2007
Changes in chloride (Cl-) homeostasis may be involved in the generation of some epileptic activities. In this study, we asked… (More)
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Highly Cited
2005
Highly Cited
2005
During development, activation of Cl−-permeable GABAA receptors (GABAA-R) excites neurons as a result of elevated intracellular… (More)
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Highly Cited
2004
Highly Cited
2004
Increased transport of Na+ across an intact blood-brain barrier (BBB) participates in edema formation during the early hours of… (More)
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Highly Cited
2004
Highly Cited
2004
GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl… (More)
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Highly Cited
1995
Highly Cited
1995
By moving chloride into epithelial cells, the Na-K-Cl cotransporter aids transcellular movement of chloride across both secretory… (More)
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Highly Cited
1994
Highly Cited
1994
By mediating the coupled movement of Na, K, and Cl ions across the plasma membrane of most animal cells, the bumetanide-sensitive… (More)
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Highly Cited
1994
Highly Cited
1994
Electrically silent Na(+)-(K+)-Cl- transporter systems are present in a wide variety of cells and serve diverse physiological… (More)
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