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Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.
It is suggested that multidrug transporters are essential parts of an innate defense system, the "chemoimmunity" network, which has a number of features reminiscent of classical immunology.
Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions.
- É. Bakos, R. Evers, E. Sinkó, A. Váradi, P. Borst, B. Sarkadi
- Biology, ChemistryMolecular pharmacology
- 1 April 2000
It is suggested that MRP2 may be responsible for the active secretion of pharmacologically relevant organic anions, such as diuretics and antibiotics, and different modulation possibilities for MRP1 or MRP 2 in drug-resistant tumor cells are indicated.
The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme*
The studies demonstrate that the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival advantage under hypoxic conditions and suggest that cells can, upon hypoxic demand, use BCRP to reduce heme or porphyrin accumulation, which can be detrimental to cells.
Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.
The role of ABC transporters in drug resistance, metabolism and toxicity.
This review provides a general overview of the human ABC transporters, their expression, localization and basic mechanism of action, and provides examples for their role in Absorption-Distribution-Metabolism-Excretion (ADME) and toxicology, and describes several basic assays which can be applied for screening drug interactions with ABCtransporters in the course of drug research and development.
High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter.
It is shown that certain TKIs, already in the clinical phase of drug development, directly interact with the ABCG2 multidrug transporter protein with a high affinity, and this data raises the possibility that an extrusion of TKI byMultidrug transporters, e.g.,ABCG2, may be involved in tumor cell TKI resistance.
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).
An inventory of the human ABC proteins.
Fluorescent cellular indicators are extruded by the multidrug resistance protein.
- L. Homolya, Z. Holló, U. Germann, I. Pastan, M. Gottesman, B. Sarkadi
- Biology, ChemistryThe Journal of biological chemistry
- 15 October 1993
The observations above suggest that dye extrusion by MDR1 may occur without a cytoplasmic appearance of the AM compounds, and call attention to the possible interaction of widely used hydrophobic fluorescent indicators with MDR 1.
Differential Modulation of the Human Liver Conjugate Transporters MRP2 and MRP3 by Bile Acids and Organic Anions*
- A. Bodó, É. Bakos, F. Szeri, A. Váradi, B. Sarkadi
- BiologyJournal of Biological Chemistry
- 27 June 2003
The different transport modulation of MRPs by bile acids and anionic drugs could play a major role in regulating physiological and pathological metabolite fluxes in the human liver.