Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Sensors and regulators of intracellular pH
- J. Casey, S. Grinstein, J. Orlowski
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 2010
Protons dictate the charge and structure of macromolecules and are used as energy currency by eukaryotic cells. The unique function of individual organelles therefore depends on the establishment and… Expand
Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization
- Tony Yeung, G. Gilbert, J. Shi, J. Silvius, A. Kapus, S. Grinstein
- Chemistry, Medicine
- Science
- 11 January 2008
Electrostatic interactions with negatively charged membranes contribute to the subcellular targeting of proteins with polybasic clusters or cationic domains. Although the anionic phospholipid… Expand
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
- R. Flannagan, G. Cosío, S. Grinstein
- Biology, Medicine
- Nature Reviews Microbiology
- 1 May 2009
Professional phagocytes have a vast and sophisticated arsenal of microbicidal features. They are capable of ingesting and destroying invading organisms, and can present microbial antigens on their… Expand
The cell biology of phagocytosis.
- R. Flannagan, Valentin Jaumouillé, S. Grinstein
- Biology, Medicine
- Annual review of pathology
- 7 February 2012
Engulfment and destruction of invading microorganisms by phagocytosis are critical components of the innate immune response. In addition, phagocytosis is also required for the clearance of apoptotic… Expand
Diversity of the mammalian sodium/proton exchanger SLC9 gene family
- J. Orlowski, S. Grinstein
- Biology, Medicine
- Pflügers Archiv
- 1 February 2004
Sodium/proton antiporters or exchangers (NHE) are integral membrane proteins present in most, if not all, living organisms. In mammals, these transporters chiefly catalyze the electroneutral exchange… Expand
Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis
- R. Botelho, M. Teruel, +5 authors S. Grinstein
- Biology, Medicine
- The Journal of cell biology
- 25 December 2000
Phagocytosis requires localized and transient remodeling of actin filaments. Phosphoinositide signaling is believed to play an important role in cytoskeletal organization, but it is unclear whether… Expand
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling
- M. Koivusalo, C. Welch, +6 authors S. Grinstein
- Biology, Medicine
- The Journal of cell biology
- 22 February 2010
Inhibitors of Na+/H+ exchange proteins block macropinocytosis by lowering the pH near the plasma membrane, which in turn inhibits actin remodeling by Rho family GTPases.
The pH of the secretory pathway: measurement, determinants, and regulation.
- Paul Paroutis, Nicolas Touret, S. Grinstein
- Biology, Medicine
- Physiology
- 1 August 2004
The luminal pH of the secretory pathway plays a critical role in the posttranslational modification and sorting of proteins and lipids. The pH of each one of the organelles that constitute the… Expand
Phagosome maturation: aging gracefully.
- O. Vieira, R. Botelho, S. Grinstein
- Biology, Medicine
- The Biochemical journal
- 15 September 2002
Foreign particles and apoptotic bodies are eliminated from the body by phagocytic leucocytes. The initial stage of the elimination process is the internalization of the particles into a plasma… Expand