Share This Author
Robust single particle tracking in live cell time-lapse sequences
This approach shows that the GTPase dynamin differentially affects the kinetics of long- and short-lived endocytic structures and that the motion of CD36 receptors along cytoskeleton-mediated linear tracks increases their aggregation probability.
Sensors and regulators of intracellular pH
A dynamic, finely tuned balance between proton-extruding andProton-importing processes underlies pH homeostasis not only in the cytosol, but in other cellular compartments as well.
Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization
- T. Yeung, G. E. Gilbert, Jialan Shi, J. Silvius, A. Kapus, S. Grinstein
- 11 January 2008
A biosensor developed to study the subcellular distribution of phosphatidylserine found that it binds the cytosolic leaflets of the plasma membrane, as well as endosomes and lysosomes.
The cell biology of phagocytosis.
Current knowledge of the cellular and molecular basis of phagosome formation and maturation is summarized and the manner in which phagocytosis is subverted by certain pathogens is discussed.
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
An overview of the antimicrobial defences of the host cell is presented, with emphasis on macrophages, for which phagocytosis has been studied most extensively and some of the evasive strategies used by bacteria are described.
Diversity of the mammalian sodium/proton exchanger SLC9 gene family
Altered NHE activity has been linked to the pathogenesis of several diseases, including essential hypertension, congenital secretory diarrhea, diabetes, and tissue damage caused by ischemia/reperfusion.
The pH of the secretory pathway: measurement, determinants, and regulation.
The methods used for measurement of pH in the secretory pathway, its determinants, and its regulation are the subjects of this review.
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling
Inhibitors of Na+/H+ exchange proteins block macropinocytosis by lowering the pH near the plasma membrane, which in turn inhibits actin remodeling by Rho family GTPases.
Phagosome maturation: aging gracefully.
The determinants and consequences of the fusion and fission reactions that underlie phagosomal maturation are the topic of this review.
Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis
The temporal sequence of phosphoinositide metabolism suggests that accumulation of 4,5-PIP2 is involved in the initial recruitment of actin to the phagocytic cup, while its degradation contributes to the subsequent cytoskeletal remodeling.