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Demonstration of a [K+,Cl-]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive…
A screening of several families of compounds on NEM-stimulated K+ efflux in human red cells allowed us to select a [(dihydroindenyl)oxy] alkanoic acid (DIOA) as the first potent inhibitor of this K+… Expand
The interaction of sodium and potassium with the sodium pump in red cells
1. At high internal K concentrations the efflux of Na from red cells increases with internal Na concentration following an S‐shaped curve. As internal K is reduced the S‐shaped region and the value… Expand
Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs
- P. Hannaert, M. Alvarez-Guerra, D. Pirot, C. Nazaret, R. Garay
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 1 February 2002
Abstract. It is generally assumed that bumetanide possesses some selectivity for the renal Na-K-Cl cotransporter NKCC2, although the results are scarce in the literature and comparisons were done… Expand
Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension.
- Miguel Rivas, R. Garay, J. Escanero, P. Cia, P. Cia, J. Alda
- The Journal of nutrition
- 1 July 2002
Soy-based diets reduce blood pressure in spontaneously hypertensive rats, but apparently not in hypertensive humans. In the present study, the antihypertensive potential of soy milk (500 mL twice… Expand
Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help.
Liver or lung metastases usually relapse under chemotherapy. Such life-threatening condition urgently needs new, systemic anticancer compounds, with original and efficient mechanisms of action. In… Expand
Inherited defect in a Na+, K+ -co-transport system in erythrocytes from essential hypertensive patients
The Na+ and K+ electrochemical gradients across cell membranes are believed to be maintained by the action of a Na+, K+-pump1–3. In human erythrocytes this pump exchanges internal Na+ for external K+… Expand
An Na+-stimulated Mg2+-transport system in human red blood cells.
The initial rate of net Mg2+ efflux was measured in human red blood cells by atomic absorption. In fresh erythrocytes incubated in Na+,K+-Ringer's medium this rate was 7.3 +/- 2.8 mumol/l cells per h… Expand
Evidence for a major route for zinc uptake in human red blood cells: [ZN(HCO3)2CL]−influx through the [CI−/HCO3−] anion exchanger
The initial rate of Zn2+ uptake in human red cells was measured by atomic absorption. A very important fraction of Zn2+ uptake was inhibited by DIDS with IC50 = 0.3 (μ)M (and by furosemide and… Expand
Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine.
- C. Arbus, A. Benyamina, +5 authors A. Hameg
- Biology, Medicine
- European journal of pharmaceutical sciences…
- 1 December 2007
Recombinant human liver microsomal enzymes of the cytochrome P450 family (CYP1A2, CYP2A6, CYP3A4, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1) were used to determine the metabolic fate of the… Expand
Na+ and K+ transport damage induced by oxygen free radicals in human red cell membranes.