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BTRC wt Allele

Known as: bTrCP1, BETA-TRCP, MGC4643 
Human BTRC wild-type allele is located in the vicinity of 10q24.32 and is approximately 204 kb in length. This allele, which encodes F-box/WD repeat… 
National Institutes of Health

Related topics

Related topics

11 relations
10q24.32Beta-Catenin Accumulation PathwayHedgehog Signaling PathwayNotch Signaling Pathway

Broader (1)

BTRC gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Transfer-NMR and docking studies identify the binding of the peptide derived from activating transcription factor 4 to protein ubiquitin ligase beta-TrCP. Competition STD-NMR with beta-catenin.
ATF4 plays a crucial role in the cellular response to stress. The E3 ubiquitin ligase, SCF beta-TrCP protein responsible for ATF4… 
2007
2007
Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells
Interferon alpha (IFNα) is widely used in treatment of malignant melanoma patients. This cytokine acts on cells by engaging Type… 
2007
2007
Somatic mutations of the beta-TrCP gene in gastric cancer.
Beta-TrCP is a component of the ubiquitin ligase complex targeting beta-catenin for proteasomal degradation, and is a negative… 
2005
2005
Expression of the Hedgehog antagonists Rab23 and Slimb/betaTrCP during mouse tooth development.
2004
2004
Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.
Processing of the p105 NF-kappaB precursor to yield the p50 active subunit is a unique and rare case in which the ubiquitin… 
Highly Cited
2003
Highly Cited
2003
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene.
beta-TrCP1 (also known as Fbw1a or FWD1) is the F-box protein component of an Skp1/Cul1/F-box (SCF)-type ubiquitin ligase complex… 
1999
1999
beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta.
We have examined the role of beta-TrCP (beta-transducin repeat-containing protein) in the ubiquitination and degradation of… 
1999
1999
A complex containing βTrCP recruits Ccd34 to catalyse ubiquitination of IκBα
1999
1999
Erratum: Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul1/F-box protein FWD1 (Proceedings of the National Academy of Sciences of the United States America (March 30…
1999
1999
Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha.
The SCF complex containing Skp1, Cul1, and the F-box protein FWD1 (the mouse homologue of Drosophila Slimb and Xenopus beta-TrCP… 
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