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BTRC wt Allele

Known as: bTrCP1, BETA-TRCP, MGC4643 
Human BTRC wild-type allele is located in the vicinity of 10q24.32 and is approximately 204 kb in length. This allele, which encodes F-box/WD repeat… 
National Institutes of Health

Related topics

Related topics

11 relations
10q24.32Beta-Catenin Accumulation PathwayHedgehog Signaling PathwayNotch Signaling Pathway

Broader (1)

BTRC gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
β-TrCP-Mediated Ubiquitination and Degradation of PHLPP1 Are Negatively Regulated by Akt
ABSTRACT PHLPP1 belongs to a novel family of Ser/Thr protein phosphatases that serve as tumor suppressors by negatively… 
Highly Cited
2008
Highly Cited
2008
A Novel Mechanism by Which Thiazolidinediones Facilitate the Proteasomal Degradation of Cyclin D1 in Cancer Cells*
This study identifies a novel mechanism by which thiazolidinediones mediate cyclin D1 repression in prostate cancer cells. Based… 
2008
2008
Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis
β-catenin accumulation is often found in lung tumors, but only a few patients have mutations in β-catenin gene. In addition… 
Highly Cited
2004
Highly Cited
2004
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
Wee1, the Cdc2 inhibitory kinase, needs to be down-regulated at the onset of mitosis to ensure rapid activation of Cdc2… 
Highly Cited
2003
Highly Cited
2003
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.
Highly Cited
2003
Highly Cited
2003
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
NF-kappaB1 p105 functions both as a precursor of NF-kappaB1 p50 and as a cytoplasmic inhibitor of NF-kappaB. Following the… 
Highly Cited
2001
Highly Cited
2001
Expression profiles of betaTRCP1 and betaTRCP2, and mutation analysis of betaTRCP2 in gastric cancer.
betaTRCP1 and betaTRCP2, components of the beta-catenin-ubiquitin ligase complex, are negative regulators of the WNT signaling… 
Highly Cited
1999
Highly Cited
1999
Inducible Degradation of IκBα by the Proteasome Requires Interaction with the F-box Protein h-βTrCP*
Activation of NF-κB transcription factors requires phosphorylation and ubiquitin-proteasome-dependent degradation of IκB proteins… 
Highly Cited
1999
Highly Cited
1999
Common Pathway for the Ubiquitination of IκBα, IκBβ, and IκBε Mediated by the F-Box Protein FWD1*
FWD1 (the mouse homolog of DrosophilaSlimb and Xenopus βTrCP, a member of the F-box- and WD40 repeat-containing family of… 
Highly Cited
1998
Highly Cited
1998
beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.
The Wnt/beta-catenin signaling pathway is responsible for the establishment of dorsoventral axis of Xenopus embryos. The recent… 
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