Hedgehog Signaling Pathway

Known as: smoothened signaling pathway, smoothened signalling pathway 
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. [GOC:mah, PMID:15205520]
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Many botanical compounds have been proposed to prevent cancer. We investigated the cancer treatment and prevention abilities of… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Accumulating evidence suggests that cancer-associated stromal fibroblasts (CAF) contribute to tumor growth by actively… (More)
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Highly Cited
2009
Highly Cited
2009
Aberrant activation of hedgehog (HH) pathway has been implicated in the development of human malignancies. This study aimed at… (More)
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Highly Cited
2007
Highly Cited
2007
Hedgehog (Hh) signaling is deregulated in multiple human cancers including pancreatic ductal adenocarcinoma (PDA). Because KRAS… (More)
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Highly Cited
2007
Highly Cited
2007
Pluripotent mesenchymal cells form a population of precursors to a variety of cell types, including osteoblasts and adipocytes… (More)
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Highly Cited
2006
Highly Cited
2006
During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here… (More)
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Highly Cited
2004
Highly Cited
2004
Previously, a small molecule, purmorphamine, was identified that selectively induces osteogenesis in multipotent mesenchymal… (More)
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Highly Cited
2004
Highly Cited
2004
Basal cell carcinomas (BCCs) express high levels of the antiapoptotic proto-oncogene, bcl-2, and we have shown that bcl-2… (More)
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Highly Cited
2000
Highly Cited
2000
Members of the vertebrate hedgehog family (Sonic, Indian, and Desert) have been shown to be essential for the development of… (More)
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Highly Cited
1996
Highly Cited
1996
Hedgehog (Hh) signaling plays a significant role in defining the polarity of a variety of tissue types along the anterior… (More)
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