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Hedgehog Signaling Pathway

Known as: smoothened signaling pathway, smoothened signalling pathway 
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. [GOC:mah, PMID:15205520]
National Institutes of Health

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36 relations
ARRB2 wt AlleleBMP2 protein, humanBMP2 wt AlleleBMP4 wt Allele

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Sonic hedgehog signaling pathwayhh signaling pathwaysmoothened signaling pathway involved in ventral spinal cord interneuron specification

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Sedum sarmentosum Bunge extract induces apoptosis and inhibits proliferation in pancreatic cancer cells via the hedgehog signaling pathway.
Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical applications including antibiosis… 
2014
2014
Molecular modeling study on the dynamical structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation.
2014
2014
Aberrant sonic hedgehog signaling pathway and STAT3 activation in papillary thyroid cancer.
The sonic hedgehog (SHH) and STAT3 signaling pathways play important roles during carcinogenesis with possible interaction. To… 
2013
2013
Expression of Bmi1, FoxF1, Nanog, and γ-Catenin in Relation to Hedgehog Signaling Pathway in Human Non-small-Cell Lung Cancer
BackgroundHedgehog signaling is known to be involved in both lung organogenesis and lung carcinogenesis. The aim of this study… 
2011
2011
Protection from lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by activation of hedgehog signaling pathway
Pulmonary microvascular endothelial cells (PMVECs) are critically involved in the pathogenesis of acute lung injury. Hedgehog… 
2010
2010
Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells.
This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in… 
2009
2009
Bortezomib reverses a post‐translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma
Tumor initiation has been attributed to haploinsufficiency at a single locus for a large number of cancers. Patched1 (Ptc1) was… 
2008
2008
Potent inhibitors of the hedgehog signaling pathway.
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR… 
2008
2008
A novel role for zebrafish zic2a during forebrain development.
2000
2000
Erythroid differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling.
Adult hematopoietic differentiation is a developmental process that employs many of the same molecular mechanisms as… 
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