A. Ciechanover

Publications370
h-index105
Citations50,914
Highly Influential Citations1,674
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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.
TLDR
It is clear now that degradation of cellular proteins is a highly complex, temporally controlled, and tightly regulated process that plays major roles in a variety of basic pathways during cell life and death as well as in health and disease.
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The ubiquitin system
TLDR
This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubiquitIn-protein ligation systems and about signals in proteins recognized by these systems.
View on Nature
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
TLDR
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
View on Springer
The ubiquitin–proteasome pathway: on protein death and cell life
TLDR
With the multiple cellular targets, it is not surprising that the ubiquitin system is involved in the regulation of many basic cellular processes such as cell cycle and division, differentiation and development, the response to stress and extracellular modulators, morphogenesis of neuronal networks, modulation of cell surface receptors, ion channels and the secretory pathway.
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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
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Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
TLDR
A nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantages and pitfalls is provided and the importance of performing multiple, methodologically unrelated assays to quantify dying and dead cells is emphasized.
View on Nature
The ubiquitin-proteasome proteolytic pathway
View on Elsevier
Proteolysis: from the lysosome to ubiquitin and the proteasome
TLDR
Several independent lines of experimental evidence strongly indicated that non-lysosomal pathways have an important role in intracellular proteolysis, although their identity and mechanisms of action remained obscure.
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Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
TLDR
It is shown that ENaC is a short‐lived protein that is ubiquitinated in vivo on the α and γ (but not β) subunits, and a paradigm for ubiquitination‐mediated regulation of ion channels is proposed.
View on Wiley
The ubiquitin system for protein degradation.
TLDR
The Ubiquitin-C-TERMINAL HYDROLASES study highlights the importance of knowing the carrier and removal status of these components in the preparation of the UBIQUITIN-MEDIATED DEGRADATION.
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