• Publications
  • Influence
Regulation of JNK signaling by GSTp
Studies of low basal Jun N‐terminal kinase (JNK) activity in non‐stressed cells led us to identify a JNK inhibitor that was purified and identified as glutathione S‐transferase Pi (GSTp) and wasExpand
  • 1,009
  • 71
MEKK1/JNK signaling stabilizes and activates p53.
Activation of the tumor suppressor p53 by stress and damage stimuli often correlates with induction of stress kinases, Jun-NH2 kinase (JNK). As JNK association with p53 plays an important role in p53Expand
  • 484
  • 26
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity
Interferons (IFNs) regulate diverse cellular functions through activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway. Lack of Ubp43, an IFN‐inducibleExpand
  • 305
  • 26
JNK targets p53 ubiquitination and degradation in nonstressed cells.
In this study we elucidated the role of nonactive JNK in regulating p53 stability. The amount of p53-JNK complex was inversely correlated with p53 level. A peptide corresponding to the JNK bindingExpand
  • 351
  • 21
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.
Growth factor-dependent accumulation of the cyclin D1 proto-oncogene is balanced by its rapid phosphorylation-dependent proteolysis. Degradation is triggered by threonine 286 phosphorylation, whichExpand
  • 187
  • 18
The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer
Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCFβ-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylatedExpand
  • 286
  • 16
SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53
Abstract Mdm2 is an E3 ubiquitin ligase for the p53 tumor suppressor protein. We demonstrate that Mdm2 is conjugated with SUMO-1 (sumoylated) at Lys-446, which is located within the RING fingerExpand
  • 292
  • 15
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.
The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc-induced apoptosis is bypassed via a critical, yet poorly understood escape mechanismExpand
  • 243
  • 10
Mdm2 association with p53 targets its ubiquitination
Key to p53 ability to mediate its multiple cellular functions lies in its stability. In the present study we have elucidated the mechanism by which Mdm2 regulates p53 degradation. Using in vitro andExpand
  • 236
  • 10
c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors*
Regulatory proteins are often ubiquitinated, depending on their phosphorylation status as well as on their association with ancillary proteins that serve as adapters of the ubiquitination machinery.Expand
  • 144
  • 10