Heat shock transcription factors: structure and regulation.
- C. Wu
- BiologyAnnual Review of Cell and Developmental Biology
- 1995
Analysis of HSF cDNA clones from many species has defined structural and regulatory regions responsible for the inducible activities of the conserved heat shock transcription factor.
Characterization of the imitation switch subfamily of ATP-dependent chromatin-remodeling factors in Saccharomyces cerevisiae.
- T. Tsukiyama, J. Palmer, C. Landel, J. Shiloach, C. Wu
- BiologyGenes & Development
- 15 March 1999
It is demonstrated that the ATP-dependent chromatin-remodeling activities are essential for the in vivo functions of both ISW1 and ISW2 complexes.
The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.
- R. Deuring, L. Fanti, J. Tamkun
- BiologyMolecules and Cells
- 1 February 2000
Regulation of heat shock factor trimer formation: role of a conserved leucine zipper.
- S. Rabindran, R. Haroun, J. Clos, J. Wisniewski, C. Wu
- BiologyScience
- 8 January 1993
The results suggest that the carboxyl-terminal zipper may suppress formation of trimers by the amino- terminal HSF zipper elements by means of intramolecular coiled-coil interactions that are sensitive to heat shock.
Molecular cloning and expression of a human heat shock factor, HSF1.
- S. Rabindran, G. Giorgi, J. Clos, C. Wu
- BiologyProceedings of the National Academy of Sciences…
- 15 August 1991
Surprisingly, an independently isolated human HSF clone, HSF2, is related to but significantly different from HSF1, suggesting that the intrinsic activity of HSF is under negative control in human cells.
Cell-free system for assembly of transcriptionally repressed chromatin from Drosophila embryos.
A cell-free system, derived from preblastoderm Drosophila embryos, for the efficient assembly of cloned DNA into chromatin that should be particularly useful for in vitro studies of chromatin assembly during DNA synthesis and for elucidating the action of transcription factors in the context of native chromatin.
Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.
- K. Sarge, V. Zimarino, K. Holm, C. Wu, R. Morimoto
- BiologyGenes & Development
- 1 October 1991
There is a striking difference in the levels of mHSF1 mRNA in different tissues of the mouse, and the ability of these two mouse heat shock factors to bind to the heat shock element (HSE) is regulated by heat.
A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression.
The results suggest that FTZ-F1 is a transcriptional activator necessary for the proper expression of the ftz gene, and the intensity of lacZ expression is reduced in transformed embryos, especially in stripes 1, 2, 3, and 6.
Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis.
- G. Lavorgna, F. Karim, C. Thummel, C. Wu
- BiologyProceedings of the National Academy of Sciences…
- 1 April 1993
A developmental isoform of FTZ-F1 is cloned and found that it is expressed as a product of the previously identified, midprepupal chromosome puff at 75CD, suggesting a role for FTZ -F1 as a regulator of insect metamorphosis.
Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK…
F focal adhesions are a major subcellular compartment where ILK functions in intracellular signal transduction, and provide important evidence for a critical role of PINCH and integrins in regulating ILK cellular function.
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