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BTRC gene

Known as: BTRC, BTRCP1, beta-transducin repeat containing E3 ubiquitin protein ligase 
This gene plays a role in the regulation of ubiquitination.
National Institutes of Health

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BTRC wt Allele
F-Box/WD Repeat-Containing Protein 1ASignal TransductionUbiquitinationbeta-Transducin Repeat-Containing Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
lincRNA-p21 Mediates the Anti-Cancer Effect of Ginkgo Biloba Extract EGb 761 by Stabilizing E-Cadherin Protein in Colon Cancer
Background Ginkgo biloba extract EGb 761 is a putative antioxidant and has been used for thousands of years to treat a variety of… 
2015
2015
A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice
Treatment of multiple myeloma with bortezomib can result in severe adverse effects, necessitating the development of targeted… 
2008
2008
Beta-catenin triggers nuclear factor kappaB-dependent up-regulation of hepatocyte inducible nitric oxide synthase.
2004
2004
HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.
The human immunodeficiency virus type 1 Vpu protein acts as an adaptor for the proteasomal degradation of CD4 by recruiting CD4… 
2004
2004
Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms.
Processing of the nf-kappab2 gene product p100 to generate p52 is a tightly regulated event, consistent with the fact that the… 
2004
2004
The role of [beta]-transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells.
OBJECTIVE Degradation of IkappaB is an essential step in nuclear factor (NF)-kappaB activation. However, the determinants… 
Highly Cited
2002
Highly Cited
2002
Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC
Aberrant activation of the Wnt signaling pathway has been reported in different human tumor types, including malignant melanomas… 
1999
1999
beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta.
We have examined the role of beta-TrCP (beta-transducin repeat-containing protein) in the ubiquitination and degradation of… 
1999
1999
Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha.
The SCF complex containing Skp1, Cul1, and the F-box protein FWD1 (the mouse homologue of Drosophila Slimb and Xenopus beta-TrCP… 
Highly Cited
1993
Highly Cited
1993
Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats
We have constructed a Xenopus oocyte cDNA library in a Saccharomyces cerevisiae expression vector and used this library to… 
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