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BTRC gene

Known as: BTRC, BTRCP1, beta-transducin repeat containing E3 ubiquitin protein ligase 
This gene plays a role in the regulation of ubiquitination.
National Institutes of Health

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BTRC wt Allele
F-Box/WD Repeat-Containing Protein 1ASignal TransductionUbiquitinationbeta-Transducin Repeat-Containing Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC
Epstein-Barr virus (EBV) infection is closely associated with tumorigenesis and development of nasopharyngeal carcinoma (NPC… 
Highly Cited
2014
Highly Cited
2014
Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation
EZH2 (enhancer of zeste homolog 2) is a critical enzymatic subunit of the polycomb repressive complex 2 (PRC2), which… 
Highly Cited
2010
Highly Cited
2010
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
DNA methyltransferase 1 (DNMT1) catalyzes DNA methylation and is overexpressed in many human diseases, including cancer. The… 
Highly Cited
2009
Highly Cited
2009
Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism
ABSTRACT The primary roles attributed to the human immunodeficiency virus type 1 (HIV-1) Vpu protein are the degradation of the… 
Highly Cited
2006
Highly Cited
2006
SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.
Skp1-cullin-F-box protein (SCF) is a multicomponent E3 ubiquitin (Ub) ligase that ubiquitinates a number of important biologic… 
Highly Cited
2006
Highly Cited
2006
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing.
Hedgehog-regulated processing of the transcription factor cubitus interruptus (Ci) in Drosophila depends on phosphorylation of… 
Highly Cited
2002
Highly Cited
2002
Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC
Aberrant activation of the Wnt signaling pathway has been reported in different human tumor types, including malignant melanomas… 
Review
1999
Review
1999
Signaling through beta-catenin and Lef/Tcf.
  • A. NovakS. Dedhar
  • Cellular and molecular life sciences : CMLS
  • 1999
  • Corpus ID: 33766473
Beta-catenin plays a structural role in cell adhesion by binding to cadherins at the intracellular surface of the plasma membrane… 
Highly Cited
1999
Highly Cited
1999
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is controlled by proteolysis of its inhibitory subunit… 
Highly Cited
1999
Highly Cited
1999
Common Pathway for the Ubiquitination of IκBα, IκBβ, and IκBε Mediated by the F-Box Protein FWD1*
FWD1 (the mouse homolog of DrosophilaSlimb and Xenopus βTrCP, a member of the F-box- and WD40 repeat-containing family of… 
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