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BECN1 gene

Known as: beclin 1, autophagy related, BECN1, VPS30 
This gene is involved in apoptosis regulation.
National Institutes of Health

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Related topics

7 relations
Antiviral ResponseApoptosisAutophagyBECN1 protein, human

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BECN1 wt Allele

Papers overview

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Highly Cited
2015
Highly Cited
2015
Cocaine-mediated microglial activation involves the ER stress-autophagy axis
Cocaine abuse leads to neuroinflammation, which, in turn, contributes to the pathogenesis of neurodegeneration associated with… 
Review
2014
Review
2014
Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers
Evidence suggests that the catabolic process of macroautophagy (autophagy hereafter) can either suppress or promote cancer. The… 
Highly Cited
2014
Highly Cited
2014
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early autophagy consists of the lipid kinase… 
Highly Cited
2014
Highly Cited
2014
Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity
Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in breast cancers implicating BECN1 loss… 
Highly Cited
2012
Highly Cited
2012
© 2012 Landes Bioscience. Do not distribute. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
Keywords: macroautophagy, mammalian autophagy regulation, microRNA, hsa-miR-376b, BECN1, Beclin 1, ATG4C, drug… 
Highly Cited
2011
Highly Cited
2011
PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment
ABSTRACT Mammary epithelial cells (MECs) detached from the extracellular matrix (ECM) produce deleterious reactive oxygen species… 
Highly Cited
2011
Highly Cited
2011
Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated
The role of intracellular Ca2+ signaling in starvation-induced autophagy remains unclear. Here, we examined Ca2+ dynamics during… 
Highly Cited
2010
Highly Cited
2010
Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
Although the essential genes for autophagy (Atg) have been identified, the molecular mechanisms through which Atg proteins… 
Highly Cited
2010
Highly Cited
2010
Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex
Autophagy is an intracellular degradation pathway that functions in protein and organelle turnover in response to starvation and… 
Highly Cited
1997
Highly Cited
1997
Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products
Mutations in the S. cerevisiae VPS29 and VPS30 genes lead to a selective protein sorting defect in which the vacuolar protein… 
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