• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy
TLDR
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Autophagy as a cell death and tumor suppressor mechanism
TLDR
The recent implication of tumor suppressors like Beclin 1, DAP-kinase and PTEN in autophagic pathways indicates a causative role for autophagy deficiencies in cancer formation and underlines the potential utility of its induction as a new cancer treatment modality. Expand
Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
TLDR
This review will mainly analyse the impact of chronic HBV infection but it is important to emphasize the potential synergistic effects between HBV and HCV, as well as between viral infections and other environmental factors, such as alcohol, chemical carcinogens and other, still poorly defined, hormonal factors which may account for the higher incidence of the tumor in man. Expand
Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
TLDR
It was found that both the inositol 1,4,5-triphosphate receptor gene and the telomerase gene were targeted by HBV in two different tumors, indicating that HBV frequently targets cellular genes involved in cell signalling and some of them may be preferential targets of the viral integration. Expand
DAPk Protein Family and Cancer
TLDR
An overview of the data connecting the DAPk family of proteins to cell death and malignant transformation is presented and the possible involvement of the autophagic cell death-inducing capacity of D APk in its tumor suppressor activity is discussed. Expand
Identification and functional characterization of a new member of the human Mcm protein family: hMcm8.
TLDR
Overall, the data identify a new Mcm protein, which does not form part of the Mcm2-7 complex and which is only structure-bound during S phase, thus suggesting its specific role in DNA replication. Expand
Autophagy and cell death.
TLDR
This chapter aims at summarizing the recent data in the field of autophagy signaling and autophagic cell death, and recognized now as a legitimate alternative death pathway to apoptosis. Expand
The dependence receptor UNC5H2 mediates apoptosis through DAP‐kinase
TLDR
It is shown that UNC5H2 physically interacts with the serine/threonine kinase death‐associated protein kinase (DAP‐kinase) both in cell culture and in embryonic mouse brains, and may regulate cell fate by controlling the proapoptotic kinase activity of DAP-kinase. Expand
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
TLDR
It is shown that miR-376b expression attenuated starvation- and rapamycin-induced autophagy in MCF-7 and Huh-7 cells and that Antagomir-mediated inactivation of the endogenous miR -376b led to an increase in ATG4C and BECN1 levels. Expand
...
1
2
3
4
5
...