Crosstalk between apoptosis and autophagy within the Beclin 1 interactome.

  title={Crosstalk between apoptosis and autophagy within the Beclin 1 interactome.},
  author={Maria Chiara Maiuri and Alfredo Criollo and Guido Kroemer},
  journal={The EMBO journal},
  volume={29 3},
Although the essential genes for autophagy (Atg) have been identified, the molecular mechanisms through which Atg proteins control 'self eating' in mammalian cells remain elusive. Beclin 1 (Bec1), the mammalian orthologue of yeast Atg6, is part of the class III phosphatidylinositol 3-kinase (PI3K) complex that induces autophagy. The first among an increasing number of Bec1-interacting proteins that has been identified is the anti-apoptotic protein Bcl-2. The dissociation of Bec1 from Bcl-2 is… CONTINUE READING


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